On the basis of the literature, as well as their own experience, the authors attempt to identify the advantages of sampling of chorionic villi over early amniocentesis in the diagnosis of diseases of the ovum.

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Embryoscopy and targeted embryo biopsy for the management of early abortion.

J Assist Reprod Genet

January 2025

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Purpose: To evaluate the safety, accuracy, and effectiveness of embryoscopy for the management of early abortion and to test the hypothesis that targeted embryo and chorionic villi sampling avoids maternal cell contamination (MCC) for genetic testing of products of conception (POC).

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The placenta is a vital organ that supports fetal development by mediating nutrient and gas exchange, regulating immune tolerance, and maintaining hormonal balance. Its formation and function are tightly linked to the processes of embryo implantation and the establishment of a robust placental-uterine interface. Recent advances in molecular biology and histopathology have shed light on the key regulatory factors governing these processes, including trophoblast invasion, spiral artery remodeling, and the development of chorionic villi.

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Article Synopsis
  • RSA is linked to metabolic imbalances at the maternal-fetal interface, especially concerning essential fatty acids and oxylipins, which may contribute to the risk of spontaneous abortion.
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The placenta, which acts as an interface between fetal and maternal circulations, is an indispensable organ for fetal growth in mammalian pregnancy. It mediates the transportation of nutrients, the exchange of gases such as oxygen and carbon dioxide, and the excretion of waste products between the fetus and mother. The surface of placental villi is covered by two layers of mononuclear undifferentiated cytotrophoblasts (CT) and multinucleated syncytiotrophoblasts (ST).

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