AI Article Synopsis
- Ocular toxoplasmosis (OT) is an eye condition caused by a parasite that leads to inflammation of the retina and choroid, affecting vision; genetic variations in cytokine genes may influence susceptibility to this disease.
- A study categorized Brazilian participants with positive toxoplasmosis serology into two groups based on the presence or absence of OT, along with a control group without infection, to examine specific gene polymorphisms' roles.
- Findings indicated that individuals with the C/C genotype of a particular gene variant were less likely to develop OT, suggesting that this genetic factor may offer protection against the condition in the studied population.
Article Abstract
Introduction: Ocular toxoplasmosis (OT) is an intraocular inflammation caused by infection that affects the retina and choroid, giving rise to posterior uveitis. Genetic polymorphisms in cytokine genes may exert influence in the expression of these molecules and play a significant role in inflammatory responses and susceptibility to OT. The aim of this study was to evaluate the role of polymorphisms rs16944 (-511 C > T) of the gene and rs1800896 (-1082 G > A) of the gene on OT in Brazilian individuals with a serologic diagnosis of and after conducting fundoscopic exams.
Methods: Participants with a positive serology were classified into two distinct groups according to the presence (G1; = 110) or absence (G2; = 104) of OT. The control group (G3) consisted of individuals without the infection (= 108).
Results: It was observed that the C/C genotype of the gene polymorphism was a protective factor for OT ( = 0.02, OR = 0.28, 95% CI 0.08-0.78 for G1 vs. G2; = 0.03; OR = 0.29, 95% CI 0.09-0.82 for G1 vs. G3), according to the recessive inheritance model.
Conclusions: The -511C.T polymorphisms of the gene seems to play an important role in the pathogenesis of OT in Brazilian individuals.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11182258 | PMC |
| http://dx.doi.org/10.3389/fopht.2023.1183167 | DOI Listing |
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