Has the human biological interaction with SARS-CoV2 variants entered a pliant "Faustian bargain"?

Pharmacol Res Perspect

Centre for Drug Repurposing and Medicines Research, University of Newcastle and Hunter Medical Research Institute, Newcastle, New South Wales, Australia.

Published: August 2024

AI Article Synopsis

  • - The authors suggest that a "Faustian bargain" exists in COVID-19, where getting a higher SARS-CoV2 viral load might reduce the risk of severe lower lung infections.
  • - This idea connects to thermodynamics and how well the virus binds to cell receptors, indicating that these scientific principles can help explain the observed health outcomes.
  • - The hypothesis aims to clarify why COVID-19 has caused varied health impacts, including both illness and death, by looking at the balance between infection levels and lung disease risk.

Article Abstract

We hypothesize that a "Faustian bargain"-the trading of increased SARS-CoV2 viral infection with a concurrent potential for prevention of life-threatening lower lung infection explains the previous and future morbidity and mortality from COVID-19. Further, this trade-off is made feasible by fundamental principles of thermodynamics and receptor affinity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11233407PMC
http://dx.doi.org/10.1002/prp2.1244DOI Listing

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