AI Article Synopsis
- The study explored the links between serum trimethylamine-N-oxide (TMAO) levels and changes in body fat distribution over time, specifically looking at a cohort of 1964 participants aged 40-75.
- Women with higher TMAO levels showed significant increases in both the fat-to-lean mass ratio (FLR) and the trunk-to-leg fat ratio (TLR) over an average follow-up of 6.2 years, whereas similar results were not found in men.
- The findings suggest that TMAO may have a stronger impact on fat distribution in older women, highlighting the need for further research in this area.
Article Abstract
Background: Trimethylamine-N-oxide (TMAO) is linked with obesity, while limited evidence on its relationship with body fat distribution. Herein, we investigated the associations between serum TMAO and longitudinal change of fat distribution in this prospective cohort study.
Methods: Data of 1964 participants (40-75y old) from Guangzhou Nutrition and Health Study (GNHS) during 2008-2014 was analyzed. Serum TMAO concentration was quantified by HPLC-MS/MS at baseline. The body composition was assessed by dual-energy X-ray absorptiometry at each 3-y follow-up. Fat distribution parameters were fat-to-lean mass ratio (FLR) and trunk-to-leg fat ratio (TLR). Fat distribution changes were derived from the coefficient of linear regression between their parameters and follow-up duration.
Results: After an average of 6.2-y follow-up, analysis of covariance (ANCOVA) and linear regression displayed women with higher serum TMAO level had greater increments in trunk FLR (mean ± SD: 1.47 ± 4.39, P = 0.006) and TLR (mean ± SD: 0.06 ± 0.24, P = 0.011). Meanwhile, for women in the highest TMAO tertile, linear mixed-effects model (LMEM) analysis demonstrated the annual estimated increments (95% CI) were 0.03 (95% CI: 0.003 - 0.06, P = 0.032) in trunk FLR and 1.28 (95% CI: -0.17 - 2.73, P = 0.083) in TLR, respectively. In men, there were no similar significant observations. Sensitivity analysis yielded consistent results.
Conclusion: Serum TMAO displayed a more profound correlation with increment of FLR and TLR in middle-aged and older community-dwelling women in current study. More and further studies are still warranted in the future.
Trial Registration: NCT03179657.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11234726 | PMC |
| http://dx.doi.org/10.1186/s12937-024-00974-w | DOI Listing |
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