2-Bromo-1-(3,3-dinitroazetidin-1-yl)ethan-1-one (RRx-001) is a hypoxic cell chemotherapeutics with already demonstrated synergism in combined chemo-radiation therapy. The interaction of the compound with secondary low-energy electrons formed in large amounts during the physico-chemical phase of the irradiation may lead to these synergistic effects. The present study focuses on the first step of RRx-001 interaction with low-energy electrons in which a transient anion is formed and fragmented. Combination of two experiments allows us to disentangle the decay of the RRx-001 anion on different timescales. Sole presence of the electron initiates rapid dissociation of NO and HNO neutrals while NO and Br anions are produced both directly and via intermediate complexes. Based on our quantum chemical calculations, we propose that bidirectional state switching between π*(NO) and σ*(C-Br) states explains the experimental spectra. The fast dynamics monitored will impact the condensed phase chemistry of the anion as well.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.202407469 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Vacancy and Low-Energy 3p-Orbital Endow NaFe(PO)(PO) Cathode with Superior Sodium Storage Kinetics.
Small
January 2025
Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Iron-based phosphate NaFe(PO)(PO) (NFPP) has been regarded as the most promising cathode for sodium-ion batteries (SIBs) thanks to its cost-effectiveness and eco-friendliness. However, it is in a predicament from the intrinsic low ionic/electronic conductivity, becoming a great challenge for its practical application. Herein, the significant roles of the low-energy 3p-orbital and transition metal vacancies are emphasized in facilitating charge rearrangement and reconstructing ion-diffusion channels, from the perspectives of crystallography and electron interaction for the first time, and the modification mechanism is fully explored by various characterizations and theoretical calculations.
View Article and Find Full Text PDFWeighted Echo State Graph Neural Networks Based on Robust and Epitaxial Film Memristors.
Adv Sci (Weinh)
January 2025
College of Physics Science & Technology, School of Life Sciences, Institute of Life Science and Green Development, Key Laboratory of Brain-Like Neuromorphic Devices and Systems of Hebei Province, Hebei University, Baoding, 071002, China.
Hardware system customized toward the demands of graph neural network learning would promote efficiency and strong temporal processing for graph-structured data. However, most amorphous/polycrystalline oxides-based memristors commonly have unstable conductance regulation due to random growth of conductive filaments. And graph neural networks based on robust and epitaxial film memristors can especially improve energy efficiency due to their high endurance and ultra-low power consumption.
View Article and Find Full Text PDFLocalized In Vivo Prodrug Activation Using Radionuclides.
J Nucl Med
January 2025
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts;
Radionuclides used for imaging and therapy can show high molecular specificity in the body with appropriate targeting ligands. We hypothesized that local energy delivered by molecularly targeted radionuclides could chemically activate prodrugs at disease sites while avoiding activation in off-target sites of toxicity. As proof of principle, we tested whether this strategy of radionuclide-induced drug engagement for release (RAiDER) could locally deliver combined radiation and chemotherapy to maximize tumor cytotoxicity while minimizing off-target exposure to activated chemotherapy.
View Article and Find Full Text PDFHerbal nanoemulsions in cosmetic science: A comprehensive review of design, preparation, formulation, and characterization.
J Food Drug Anal
December 2024
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
The rapid development of delivery systems for cosmetics has revealed two critical challenges in the field: enhancing the solubility of active ingredients and ensuring the stability of natural materials used in cosmetics. Nanoemulsion technology has emerged as an indispensable solution for addressing these challenges, not only enhancing the stability of cosmetics but also improving the solubility of pharmaceuticals and active ingredients with poor solubility. Nanoemulsion formulations have reinforced stability and amended the bioavailability of hydrophobic drugs.
View Article and Find Full Text PDFEffects of Temperature Fluctuations on Surface Mobility of Atomic Steps and Oxidation Dynamics in High-Temperature Alloys.
J Am Chem Soc
January 2025
Department of Mechanical Engineering & Materials Science and Engineering Program, State University of New York at Binghamton, Binghamton, New York 13902, United States.
In contrast to the traditional perspective that thermal fluctuations are insignificant in surface dynamics, here we report their influence on surface reaction dynamics. Using real-time low-energy electron microscopy imaging of NiAl(100) under both vacuum and O atmospheres, we demonstrate that transient temperature variations substantially alter the direction of atom diffusion between the surface and bulk, leading to markedly different oxidation outcomes. During heating, substantial outward diffusion of atoms from the bulk to the surface results in step growth.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!