AI Article Synopsis
- The study aimed to determine if preoperative treatment for pancreatic cancer increases the risk of developing hepatic steatosis (HS) and if HS impacts short-term surgical recovery.
- It involved reviewing medical records of 230 patients who underwent surgery from 2010 to 2023, identifying various risk factors for HS, including factors like female sex, disease stage, and preoperative chemotherapy.
- Results showed that while preoperative HS was linked to several risk factors, it did not influence short-term postoperative complications.
Article Abstract
Purpose: We investigated whether the preoperative treatment of patients with pancreatic cancer is a risk factor for hepatic steatosis (HS), and whether preoperative HS affects the short-term postoperative outcomes.
Methods: Patients who underwent radical surgery for pancreatic cancer between 2010 and 2023 were enrolled. The patients' medical records were reviewed. Albumin and carbohydrate antigen 19-9 were measured before and after chemotherapy in the patients who received preoperative chemotherapy. A logistic regression univariate analysis was performed to analyze the factors associated with new-onset HS.
Results: A total of 230 patients who underwent surgery were included. HS was observed on the date of surgery in 11 (10%) and two (2%) patients with and without preoperative chemotherapy, respectively. Female sex, initially borderline resectable or unresectable disease, history of cholangitis, presence of PEI, long-term (≥ 3 months) biliary drainage, preoperative chemotherapy, and serum albumin ≥ 3.9 mg/dl before chemotherapy were identified as risk factors for HS. The incidence of postoperative morbidity did not differ between the patients with and without preoperative steatosis.
Conclusions: Preoperative chemotherapy, a history of cholangitis, the presence of PEI, and ≥ 3 months' duration of biliary drainage were risk factors for the development of HS before surgery for pancreatic cancer. However, preoperative HS did not affect the short-term postoperative outcomes.
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| http://dx.doi.org/10.1007/s00595-024-02895-x | DOI Listing |
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