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Predictive approaches and rules to connect and combine molecular circuit components are required to realize the potential of molecular electronics and develop miniaturized integrated circuits. To this end, we have recently demonstrated a bis(terpyridine)-based molecular breadboard with four conductance states formed by the superposition of five 2-5 ring circuits. Here, we develop a generic analytical/statistical model to describe break-junction data and use it to extract the conductance of the five embedded circuits in the bis-terpyridine-based molecular breadboard junction.

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A mononuclear iron(II) complex constructed using a complementary ligand pair exhibits intrinsic luminescence-spin-crossover coupling.

Dalton Trans

January 2025

State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, School of Chemical Engineering, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, P. R. China.

Molecular materials that exhibit synergistic coupling between luminescence and spin-crossover (SCO) behaviors hold significant promise for applications in molecular sensors and memory devices. However, the rational design and underlying coupling mechanisms remain substantial challenges in this field. In this study, we utilized a luminescent complementary ligand pair as an intramolecular luminophore to construct a new Fe-based SCO complex, namely [FeLL](BF)·HO (1-Fe, L is a 2,2':6',2''-terpyridine (TPY) derivative ligand and L is 2,6-di-1-pyrazol-1-yl-4-pyridinecarboxylic acid), and two isomorphic analogs (2-Co, [CoLL](BF)·HO and 3-Zn, [ZnLL](BF)·HO).

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The nucleotides play multiple fundamental roles that are essential in biochemical enzymatic reactions and signaling pathways. Many diseases are closely associated with their dysregulation. Therefore, reliable and sensitive optical probes to discriminate various nucleotides are essential in biochemistry, drug discovery, and disease diagnosis.

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Copper Chelate Targeting Externalized Phosphatidylserine Inhibits PD-L1 Expression and Enhances Cancer Immunotherapy.

J Am Chem Soc

January 2025

Department of Pharmacy, The First Affiliated Hospital of USTC; Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui Provincial Key Laboratory of Precision Pharmaceutical Preparation and Clinical Pharmacy, Hefei, Anhui 230026, China.

Inhibitors of the PD-1/PD-L1 immune checkpoint have revolutionized cancer treatment. However, the clinical response remains limited, with only 20% of patients benefiting from treatment and approximately 60% of PD-L1-positive patients exhibiting resistance. One key factor contributing to resistance is the externalization of phosphatidylserine (PS) on the surface of cancer cells, which suppresses immune responses and promotes PD-L1 expression, further hindering the efficacy of PD-L1 blockade therapies.

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Fluorescent Polymers via Coordination of -Terpyridine Ligands with Transition Metals and Their pH Response Properties.

Polymers (Basel)

December 2024

Department of Organic and Polymer Chemistry, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.

Stimulus-responsive luminescent materials are pivotal in the field of sensing. Fluorescent transition metal complexes with a charge transfer excited state, especially terpyridine-coordinated polymers, are of particular interest due to their tunable emission. In this paper, a novel bis-terpyridine ligand was synthesized and assembled into a coordination polymer, which showed intense visible light absorption and fluorescence emission in the solid state that could be regulated by an acidic or basic pH.

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