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Evidence of synergistic mechanisms of hepatoprotective botanical herbal preparation of and . | LitMetric

Evidence of synergistic mechanisms of hepatoprotective botanical herbal preparation of and .

Front Pharmacol

State Key Laboratory of Research and Development of Characteristic Qin Medicine Resources (Cultivation), and Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, China.

Published: June 2024

AI Article Synopsis

  • The study looks at two traditional plants, PM (Willd.) and SS (Rehder & Wilson), which are used for liver health and can help treat liver injury.
  • Scientists tested how well these plants work together in mice with liver problems and found that using them together works better than using just one.
  • They discovered that their combined effects help the body fix itself by changing several important processes and targeting specific genes that help protect the liver.

Article Abstract

Background: (Willd.) Maesen & S.M.Almeida ex Sanjappa & Predeep (syn. (Willd.) Ohwi) and Rehder & E.H. Wilson are traditional edible and medicinal hepatoprotective botanical drugs. Studies have shown that the combination of two botanical drugs enhanced the effects of treating acute liver injury (ALI), but the synergistic effect and its action mechanisms remain unclear. This study aimed to investigate the synergistic effect and its mechanism of the combination of (Willd.) Maesen & S.M.Almeida ex Sanjappa & Predeep (syn. (Willd.) Ohwi) (PM) and Rehder & E.H. Wilson (SS) in the treatment of ALI.

Methods: High performance liquid chromatography (HPLC) were utilized to conduct the chemical interaction analysis. Then the synergistic effects of botanical hybrid preparation of PM-SS (BHP PM-SS) against ALI were comprehensively evaluated by the CCl induced ALI mice model. Afterwards, symptom-oriented network pharmacology, transcriptomics and metabolomics were applied to reveal the underlying mechanism of action. Finally, the key target genes were experimentally by RT-qPCR.

Results: Chemical analysis and pharmacodynamic experiments revealed that BHP PM-SS was superior to the single botanical drug, especially at 2:3 ratio, with a better dissolution rate of active ingredients and synergistic anti-ALI effect. Integrated symptom-oriented network pharmacology combined with transcriptomics and metabolomics analyses showed that the active ingredients of BHP PM-SS could regulate Glutathione metabolism, Pyrimidine metabolism, Arginine biosynthesis and Amino acid sugar and nucleotide sugar metabolism, by acting on the targets of AKT1, TNF, EGFR, JUN, HSP90AA1 and STAT3, which could be responsible for the PI3K-AKT signaling pathway, MAPK signaling pathway and Pathway in cancer to against ALI.

Conclusion: Our study has provided compelling evidence for the synergistic effect and its mechanism of the combination of BHP PM-SS, and has contributed to the development and utilization of BHP PM-SS dietary supplements.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228302PMC
http://dx.doi.org/10.3389/fphar.2024.1412816DOI Listing

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