A catalyst- and additive-free synthesis of 2-benzyl -substituted anilines from ()-2-arylidene-3-cyclohexenones and primary amines has been reported. The reaction proceeds smoothly through a sequential imine condensation-isoaromatization pathway, affording a series of synthetically useful aniline derivatives in acceptable to high yields. Mild reaction conditions, no requirement of metal catalysts, operational simplicity and the potential for scale-up production are some of the highlighted advantages of this transformation.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228828 | PMC |
http://dx.doi.org/10.3762/bjoc.20.130 | DOI Listing |
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