A total of 82 patients and healthy subjects in the First Affiliated Hospital of Sun Yat-sen University from March to August 2023 were recruited. The cohort consisted of 43 patients with head and neck squamous cell carcinoma (HNSCC) and 39 non-cancer patients or healthy subjects. There were 63 males and 19 females, with a median age of 62 (46, 67) years. The levels of folate receptor-positive circulating tumor cells (FRCTCs) in the blood of HNSCC patients and non-cancer/healthy subjects were 12.4 (8.5, 17.8) floate unit (FU)/3 ml and 5.0 (3.8, 6.6) FU/3 ml, respectively, with a statistically significant difference (<0.001). The area under the receiver operating characteristic (ROC) curve for FRCTCs levels was 0.937 (95%: 0.888-0.986, <0.001), with a cut-off value of 7.4 FU/3 ml determined by the maximum Youden index. At this cut-off value, the sensitivity and specificity of FRCTCs for diagnosing HNSCC were 90.70% and 89.74%, respectively. The current study suggests that FRCTCs could be used as a liquid biopsy marker for the screening and diagnosis of HNSCC.
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| http://dx.doi.org/10.3760/cma.j.cn112137-20231222-01465 | DOI Listing |
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