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The relationship between muscle and bone tissues is crucial in understanding musculoskeletal health, focusing on how they communicate with each other.
Recent studies emphasize the importance of lipid signaling—specifically phospholipids, sphingolipids, and eicosanoids—in regulating cellular functions and metabolic processes in these tissues.
The chapter also discusses the consequences of impaired lipid signaling on musculoskeletal disorders and explores potential therapeutic strategies for improving treatment options.
Article Abstract
The intricate interplay between the muscle and bone tissues is a fundamental aspect of musculoskeletal physiology. Over the past decades, emerging research has highlighted the pivotal role of lipid signaling in mediating communication between these tissues. This chapter delves into the multifaceted mechanisms through which lipids, particularly phospholipids, sphingolipids, and eicosanoids, participate in orchestrating cellular responses and metabolic pathways in both muscle and bone. Additionally, we examine the clinical implications of disrupted lipid signaling in musculoskeletal disorders, offering insights into potential therapeutic avenues. This chapter aims to shed light on the complex lipid-driven interactions between the muscle and bone tissues, paving the way for a deeper understanding of musculoskeletal health and disease.
