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Recent Progress in Synthetic and Biological Application of Diorganyl Diselenides. | LitMetric

Recent Progress in Synthetic and Biological Application of Diorganyl Diselenides.

Chem Rec

Laboratório de Síntese, Reatividade, Avaliação Farmacológica e Toxicológica de Organocalcogênios CCNE, UFSM, Santa Maria, Rio Grande do Sul, Brazil, 97105-900.

Published: July 2024

AI Article Synopsis

  • Diorganyl diselenides are easy to prepare, feature unique reactivity, and have wide-ranging biological activities, making them valuable in organic chemistry.
  • They serve as electrophiles in various reactions, such as organoselenylation of aromatic systems and peptides, and have applications in reducing alkenes and nucleophilic substitution.
  • The review highlights advancements in their transformations and discusses their pharmacological effects, including anti-inflammatory, hypoglycemic, chemotherapeutic, and antimicrobial properties, offering important information for researchers and industry professionals.

Article Abstract

Diorganyl diselenides have emerged as privileged structures because they are easy to prepare, have distinct reactivity, and have broad biological activity. They have also been used in the synthesis of natural products as an electrophile in the organoselenylation of aromatic systems and peptides, reductions of alkenes, and nucleophilic substitution. This review summarizes the advancements in methods for the transformations promoted by diorganyl diselenides in the main functions of organic chemistry. Parallel, it will also describe the main findings on pharmacology and toxicology of diorganyl diselenides, emphasizing anti-inflammatory, hypoglycemic, chemotherapeutic, and antimicrobial activities. Therefore, an examination detailing the reactivity and biological characteristics of diorganyl diselenides provides valuable insights for academic researchers and industrial professionals.

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Source
http://dx.doi.org/10.1002/tcr.202400044DOI Listing

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