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Higher Prevalence of Common Neurological Soft Signs in Essential Tremor With Midline Distribution: A Multicenter Cohort Study.
J Clin Neurol
March 2025
Department of Geriatric Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Background And Purpose: Essential tremor with a midline distribution (Mid-ET) may represent a distinct subtype of essential tremor (ET) that primarily affects midline structures, often indicating advanced disease stage and increased severity. Recent studies have highlighted the complexity of Mid-ET, but research on neurological soft signs (NSS) in Mid-ET remains insufficient.
Methods: The patients with ET included in this cross-sectional study were divided into two subgroups based on whether or not the ET had a midline distribution: Mid-ET and No-Mid-ET.
Ultrasound-Guided Botulinum Toxin Infiltrations in Essential Tremor Patients: A 36-week Follow Up.
Tremor Other Hyperkinet Mov (N Y)
March 2025
Department of Neurology, Consorci Sanitari de Terrassa, Barcelona, Spain.
Background: Essential tremor (ET) presents therapeutic challenges as oral therapies, are often partially effective and carry adverse effects. Deep Brain Stimulation and High-intensity Focused Ultrasound targeting the ventral intermediate thalamic nucleus show efficacy in managing ET; however, their cost and invasiveness deter some patients. Botulinum toxin infiltrations for ET in the upper limbs have been limited by adverse effects.
View Article and Find Full Text PDFSafety of Focused Ultrasound Ablation in Parkinson's Disease: A Meta-Analysis of Randomized Controlled Trials.
J Clin Neurosci
March 2025
Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA.
Introduction: Magnetic resonance-guided focused ultrasound (MRgFUS) is well-established for the treatment of essential tremor and is emerging as a promising non-incisional treatment for Parkinson's disease (PD). However, its safety in this context is not well established.
Methods: We performed a systematic review and meta-analysis to evaluate the incidence of adverse events among patients with medication-refractory PD treated with MRgFUS.
Cerebellar transcranial magnetic stimulation in essential tremor: a systematic review and meta-analysis of safety and efficacy.
Acta Neurol Belg
March 2025
Department of Neurology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Background: Essential tremor (ET) is a common neurological disorder that significantly impacts daily activities. This meta-analysis aims to evaluate the safety and efficacy of cerebellar repetitive Transcranial Magnetic Stimulation (rTMS) and cerebellar Theta Burst Stimulation (TBS) in treating ET.
Methods: We searched through June 14, 2024, four databases (Scopus, PubMed, Web of Science, and Cochrane CENTRAL) to identify clinical trials investigating cerebellar rTMS or TBS in ET patients.
Effect of deep brain stimulation on nonmotor symptoms in essential tremor.
J Neurosurg
March 2025
2Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville.
Objective: Essential tremor (ET) is a prevalent movement disorder that also includes nonmotor symptoms such as anxiety, depression, and cognitive impairment. Deep brain stimulation (DBS) is an established treatment for ET, yet its impact on nonmotor symptoms remains unclear. This study aims to describe neuropsychological outcomes following ventral intermediate nucleus (VIM) DBS in a large cohort of patients with ET and identify factors associated with changes in depression and cognitive function.
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