A laboratory-scale mesophilic submerged anaerobic hybrid membrane bioreactor (An-HMBR) was operated for 270 days for the treatment of high-strength synthetic wastewater at different hydraulic retention times (HRTs) (3 days, 2 days, 1 day, and 0.5 days). Chemical oxygen demand (COD) removal efficiency of 92% was obtained with methane yield rate of 0.18 LCH/g COD at 1-day HRT. The results of lab scale reactor at 1-day HRT were utilized for upscaling and cost analysis. Cost analysis revealed that the total capital cost comprised tank system (48%), membrane cost (32%), screen and PUF sponge (5% each), PLCs (4%), liquid pumps (3%), and others (2%). The operational cost comprised chemical cost (46%), pumping energy (42%), and sludge disposal (12%). The results revealed that the tank and heating costs accounted for the largest fraction of the total life cycle cost for full-scale An-HMBR. The heating cost can be compensated by gas recovery. Sensitivity analysis revealed that the interest rates, influent flow, and membrane flux were the most crucial parameters which affected the total cost of An-HMBR.
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