AI Article Synopsis
- Three chromomycin derivatives were identified from soil bacteria, specifically chromomycins A and monodeacetylchromomycin A, with their structures and absolute configurations analyzed using advanced techniques like NMR.
- These compounds demonstrated strong cytotoxic effects against various non-small-cell lung cancer (NSCLC) cells and were found to lower the protein levels of c-FLIP in one of the cancer cell lines.
- In animal studies, the chromomycins were more effective at inhibiting tumor growth in specific conditions, indicating that c-FLIP plays a significant role in the anticancer activity of these compounds.
Article Abstract
Three chromomycin derivatives, chromomycins A ( CA), A ( CA), and monodeacetylchromomycin A ( MDA-CA), were identified from the soil-derived sp. CGMCC 26516. A reinvestigation of the structure of CA is reported, of which the absolute configuration was unambiguously determined for the first time to be identical with that of CA based on nuclear magnetic resonance (NMR) data analysis as well as NMR and electronic circular dichroism calculations. Compounds showed potent cytotoxicity against the non-small-cell lung cancer (NSCLC) cells (A549, H460, H157-c-FLIP, and H157-LacZ) and down-regulated the protein expression of c-FLIP in A549 cells. The IC values of chromomycins in H157-c-FLIP were higher than that in H157-LacZ. Furthermore, si-c-FLIP promoted anti-proliferation effect of chromomycins in NSCLC cells. In nude mice xenograft model, and both showed more potent inhibition on the growth of H157-lacZ xenografts than that of H157-c-FLIP xenografts. These results verify that c-FLIP mediates the anticancer effects of chromomycins in NSCLC.
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| http://dx.doi.org/10.1080/10286020.2024.2375288 | DOI Listing |
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