Objectives: To establish a reliable ultrasound (US) method of evaluating dynamic extrusion of lateral meniscus in healthy population, and to investigate the pattern of dynamic meniscus extrusion (ME) in lateral meniscus under loading conditions.

Methods: The lateral ME was examined via US method in unloaded, double-leg standing, and single-leg standing positions. Two different US measurement methods were compared to the magnetic resonance imaging (MRI) results to determine the optimal measurement methods. The US results obtained by different researchers were tested for interobserver consistency and the results obtained by the same researcher on two separate days were tested for intraobserver consistency. The patterns of dynamic extrusion were compared between medial and lateral sides.

Results: A total of healthy 44 volunteers were included in the study, with 86 knees assessed by US, and 25 knees evaluated by MRI. The US evaluation of dynamic lateral ME demonstrated excellent interobserver and intraobserver reliability. The US measurements using method A were consistent with the MRI results with no significant difference (P = .861, intraclass correlation coefficient [ICC] = 0.868), while method B underestimated the lateral ME compared to MRI (P = .001, ICC = 0.649). Lateral ME decreased slightly from unloaded (1.0 ± 0.8 mm) to single-leg standing position (0.8 ± 0.8 mm), whereas medial ME increased significantly in both double-leg and single-leg standing positions (2.4 ± 0.7 mm, 2.6 ± 0.7 mm).

Conclusion: A novel US evaluation method of lateral ME was established with reliable and accurate results compared to the MRI. Lateral ME in healthy populations decreased slightly as the loadings increased, which was different from the pattern of dynamic extrusion in medial meniscus.

Download full-text PDF

Source
http://dx.doi.org/10.1002/jum.16507DOI Listing

Publication Analysis

Top Keywords

dynamic extrusion
20
extrusion lateral
12
lateral meniscus
12
single-leg standing
12
lateral
11
ultrasound method
8
method evaluating
8
evaluating dynamic
8
meniscus healthy
8
healthy population
8

Similar Publications

Tailoring the Reprocessability of Thiol-Ene Networks through Ring Size effects.

Angew Chem Int Ed Engl

December 2024

Ghent University: Universiteit Gent, Department of Organic and Macromolecular Chemistry, Krijgslaan 281 S4, 9000, Ghent, BELGIUM.

Recycling thermosetting materials presents itself as a major challenge in achieving sustainable material use. Dynamic covalent cross-linking of polymers has emerged as a viable solution that can combine the structural integrity of thermosetting materials with the (re-)processability of thermoplastics. Thioether linkages between polymer chains are quite common, and their use dates back to the vulcanization of rubbers.

View Article and Find Full Text PDF

LDB1 establishes multi-enhancer networks to regulate gene expression.

Mol Cell

December 2024

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Division of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. Electronic address:

How specific enhancer-promoter pairing is established remains mostly unclear. Besides the CTCF/cohesin machinery, few nuclear factors have been studied for a direct role in physically connecting regulatory elements. Using a murine erythroid cell model, we show via acute degradation experiments that LDB1 directly and broadly promotes connectivity among regulatory elements.

View Article and Find Full Text PDF

After birth, tissues grow continuously until reaching adult size, with each organ exhibiting unique cellular dynamics, growth patterns, and (stem or non-stem) cell sources. Using a suite of experimental and computational multiscale approaches, we found that aortic expansion is guided by specific biological principles and scales with the vertebral column rather than animal body weight. Expansion proceeds via two distinct waves of arterial cell proliferation along blood flow that are spatially stochastic, yet temporally coordinated.

View Article and Find Full Text PDF

The Influence of the Steam Sterilization Process on Selected Properties of Polymer Samples Produced in MEX and JMT Processes.

Materials (Basel)

November 2024

Institute of Robots and Machines Design, Faculty of Mechanical Engineering, Military University of Technology, gen. Sylwestra Kaliskiego 2 St., 00-908 Warsaw, Poland.

Polymeric materials are widely used in medical engineering, and with the dynamic development of additive manufacturing (AM) technology, increasing attention is being paid to research on the mechanical strength of composite polymer structures. At the same time, the impact of sterilization on, for example, surgical templates and the influence of the sterilization process on the geometry of these parts have not been sufficiently studied. In this work, the effect of steam sterilization on samples made of polymer materials for medical applications was presented.

View Article and Find Full Text PDF

Transcription processes compete with loop extrusion to homogenize promoter and enhancer dynamics.

Sci Adv

December 2024

Department of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), UMR7104, Centre National de la Recherche Scientifique, U1258, Institut National de la Santé et de la Recherche Médicale, University of Strasbourg, 6704 Illkirch, France.

The spatiotemporal configuration of genes with distal regulatory elements is believed to be crucial for transcriptional control, but full mechanistic understanding is lacking. We combine simultaneous live tracking of pairs of genomic loci and nascent transcripts with molecular dynamics simulations to assess the gene and its enhancer. We find that both loci exhibit more constrained mobility than control sequences due to stalled cohesin at CCCTC-binding factor sites.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!