AI Article Synopsis
- A mumps outbreak in 2017 among U.S. military personnel led researchers to study pre-exposure serum samples to evaluate antibody levels in those who developed mumps versus those who did not.
- The study found that individuals who developed mumps had significantly lower pre-outbreak neutralizing antibody levels compared to those who remained healthy.
- The results suggest that certain levels of mumps neutralizing antibodies may help protect against infection from the vaccine strain and wildtype virus, highlighting their potential role in immunity.
Article Abstract
Background: In 2017, a mumps outbreak occurred in a US military barracks. Serum collected at service entry was used to compare pre-exposure with presumptive vaccine-induced antibody levels from persons who developed mumps (cases) and potentially exposed persons who did not develop mumps (non-cases). Sufficient information to determine levels of exposure during the outbreak was not available.
Methods: Pre-outbreak serum samples from the Department of Defense Serum Repository were available from 254 potentially exposed service members. Twelve developed clinical symptoms and had post-outbreak serum collected. All sera were tested with a mumps-specific enzyme immunoassay for immunoglobulin M, immunoglobulin G (IgG), and IgG avidity. The neutralizing antibodies to vaccine strain (Jeryl Lynn [JL], genotype A) and wildtype virus (genotype G) was assessed by a plaque reduction neutralization test. A Fisher exact test and receiver operator characteristic curve were used to analyze the antibody response for non-cases and mumps cases.
Results: Eight mumps cases were laboratory confirmed. Pre-outbreak neutralizing antibody titers to JL and genotype G mumps virus and pre-outbreak IgG index values were proportionately lower for most cases as compared with exposed non-cases. When compared with potentially exposed non-cases, cases with clinical symptoms had greater odds of having a pre-outbreak JL titer <41 and a genotype G titer <16.
Conclusions: We identified potential correlates of protection for mumps neutralizing antibody titers against JL and genotype G mumps viruses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11227222 | PMC |
| http://dx.doi.org/10.1093/ofid/ofae329 | DOI Listing |
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