AI Article Synopsis
- Exosomes are tiny vesicles crucial for intercellular communication, containing important biological materials and produced by most human cells, found in body fluids like urine and blood.* -
- The study reviews urinary exosomes' characteristics, methods for isolating and analyzing them, and their potential as diagnostic tools for bladder cancer, a common and aggressive tumor.* -
- Findings suggest that urinary exosomes could serve as valuable molecular biomarkers for early bladder cancer detection, although there are current limitations to their use.*
Article Abstract
Background: The exosome is a critical component of the intercellular communication., playing a vital role in regulating cell function. These small vesicles contain proteins, mRNAs, miRNAs, and lncRNAs, surrounded by lipid bilayer substances. Most cells in the human body can produce exosomes, released into various body fluids such as urine, blood, and cerebrospinal fluid. Bladder cancer is the most common tumor in the urinary system, with high recurrence and metastasis rates. Early diagnosis and treatment are crucial for improving patient outcomes.
Methods: This study employed the PubMed search engine to retrieve publicly accessible data pertaining to urinary exosomes.
Results: We summarize the origins and intricate biological characteristics of urinary exosomes, the introduction of research methodologies used in basic experiments to isolate and analyze these exosomes, the discussion of their applications and progress in the diagnosis and treatment of bladder cancer, and the exploration of the current limitations associated with using urinary exosomes as molecular biomarkers for diagnosing bladder cancer.
Conclusion: Exosomes isolated from urine may be used as molecular biomarkers for early detection of bladder cancer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11226776 | PMC |
| http://dx.doi.org/10.1016/j.heliyon.2024.e32621 | DOI Listing |
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