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Prognostic significance of serum Chemerin and neutrophils levels in patients with oral squamous cell carcinoma. | LitMetric

AI Article Synopsis

  • The study investigates the role of Chemerin, a multifunctional protein, in predicting cancer risk and mortality in patients with oral squamous cell carcinoma (OSCC).
  • It includes 120 OSCC patients, measuring serum Chemerin and neutrophil levels and analyzing their relation to patient outcomes using various laboratory techniques.
  • Results show higher Chemerin and neutrophil levels correlate with poorer survival rates, indicating that these factors could serve as important biomarkers for assessing OSCC prognosis and disease severity.

Article Abstract

Objectives: Chemerin, as a novel multifunctional adipokine, is proposed to be involved in high cancer risk and mortality. The present study was aimed to evaluate the prognostic value of serum Chemerin and neutrophils in patients with oral squamous cell carcinoma (OSCC).

Materials And Methods: 120 patients with OSCC were included in this prospective cohort study. The levels of serum Chemerin were measured by enzyme-linked immunosorbent assay (ELISA). We also explored the possible effects of Chemerin on neutrophils' chemokines in OSCC using a real-time PCR, western blotting.

Results: Levels of serum Chemerin, neutrophils and NLR were significantly higher among non-survivors compared to survivors of OSCC (both  < 0.05). Higher serum Chemerin levels were associated with advanced TNM stage, lymph node metastasis, differentiation and tumor recurrence (both  < 0.05). Serum Chemerin levels correlated with neutrophils and NLR levels (r = 0.708, r = 0.578, both  < 0.05). Based on ROC analysis, Chemerin + NLR predicted OSCC patient mortality with 81.54 % sensitivity and 87.27 % specificity, with an AUC of 0.8898. In a Kaplan-Meier analysis, high serum Chemerin levels, high neutrophil levels and high NLR levels were associated with shorter overall and disease-free survival (both  < 0.05). A univariate and multivariate Cox regression analysis showed that serum Chemerin and neutrophils were independent risk factors for OSCC. (both  < 0.05). QRT-PCR and western blotting results showed that Chemerin upregulated the expression of chemokines IL-17 and CXCL-5 in neutrophils (both  < 0.05).

Conclusions: Our study suggests that measurement of serum Chemerin and neutrophils might be a useful diagnostic and prognostic biomarker for OSCC patients. Chemerin may promote neutrophils infiltration in OSCC through upregulation of chemokines IL17 and CXCL-5.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11225754PMC
http://dx.doi.org/10.1016/j.heliyon.2024.e32393DOI Listing

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