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Preparation of gastrodin-modified dendrimer-entrapped gold nanoparticles as a drug delivery system for cerebral ischemia-reperfusion injury.
Brain Behav
December 2022
Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Objective: This study sought to evaluate the feasibility of multifunctional gastrodin (GAS)-containing nano-drug carrier system against cerebral ischemia-reperfusion injury (CIRI).
Methods: The drug-loaded nanocomposite (Au-G5.NHAc-PS/GAS) with certain encapsulation efficiency (EE) was prepared by physical adsorption method using different proportions of GAS and drug-carrying system (Au-G5.
[Short-term effect of gas explosion in real roadway environment on rats' brain neural behavior].
Wei Sheng Yan Jiu
November 2020
Institutes of Health Central Plains, Xinxiang Medical University, Xinxiang 453003, China.
Objective: To study the effect of gas explosion on brain nerve behavior of rats in real roadway environment.
Methods: Before the gas explosion, the real gas explosion roadway environment was simulated by using the roadway and explosion test system of gas explosion test in a large coal mine in Chongqing Research Institute of China Coal Science & Technology Group, and cage fixation and explosion parameter setting were carried out. That was to use the equivalent of 9.
Argon treatment after experimental subarachnoid hemorrhage: evaluation of microglial activation and neuronal survival as a subanalysis of a randomized controlled animal trial.
Med Gas Res
July 2021
Department of Neurosurgery, RWTH Aachen University Hospital, Aachen, Germany.
Hereinafter, we evaluate argon's neuroprotective and immunomodulatory properties after experimental subarachnoid hemorrhage (SAH) examining various localizations (hippocampal and cortical regions) with respect to neuronal damage and microglial activation 6, 24 and 72 hours after SAH. One hour after SAH (endovascular perforation rat model) or sham surgery, a mixture of gas containing 50% argon (argon group) or 50% nitrogen (control group) was applied for 1 hour. At 6 hours after SAH, argon reduced neuronal damage in the hippocampal regions in the argon group compared to the control group (P < 0.
View Article and Find Full Text PDFEffects of Acute Systemic Hypoxia and Hypercapnia on Brain Damage in a Rat Model of Hypoxia-Ischemia.
PLoS One
July 2017
Department of Anesthesiology, Second Affiliated Hospital of Harbin Medical University P. R. China; and Anesthesiology Key Laboratory, Education Department, Harbin Medical University, Heilongjiang Province, P. R. China.
Therapeutic hypercapnia has the potential for neuroprotection after global cerebral ischemia. Here we further investigated the effects of different degrees of acute systemic hypoxia in combination with hypercapnia on brain damage in a rat model of hypoxia and ischemia. Adult wistar rats underwent unilateral common carotid artery (CCA) ligation for 60 min followed by ventilation with normoxic or systemic hypoxic gas containing 11%O2,13%O2,15%O2 and 18%O2 (targeted to PaO2 30-39 mmHg, 40-49 mmHg, 50-59 mmHg, and 60-69 mmHg, respectively) or systemic hypoxic gas containing 8% carbon dioxide (targeted to PaCO2 60-80 mmHg) for 180 min.
View Article and Find Full Text PDFRapidly Progressive Gas-containing Lumbar Spinal Epidural Abscess.
Korean J Spine
September 2015
Department of Neurosurgery, Dongguk University Ilsan Hospital, Goyang, Korea and Dongguk University, Seoul, Korea.
Gas-containing (emphysematous) infections of the abdomen, pelvis, and extremities are well-known disease entities, which can potentially be life-threatening. They require aggressive medical and often surgical treatment. In the neurosurgical field, some cases of gas-containing brain abscess and subdural empyema have been reported.
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