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Stargardt disease is a currently untreatable, inherited neurodegenerative disease that leads to macular degeneration and blindness due to loss-of-function mutations in the ABCA4 gene. We have designed a dual adeno-associated viral vector encoding a split-intein adenine base editor to correct the most common mutation in ABCA4 (c.5882G>A, p.
View Article and Find Full Text PDFA rapid, multiplexed and naked-eye readable paper assay for detecting heavy metal pollution in food using a catalytic colorimetric reaction.
J Dairy Sci
January 2025
College of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, China. Electronic address:
Heavy metal contamination is a serious food safety issue. Herein, we report a rapid, multiplexed and naked-eye readable method for detecting heavy metal pollution in food samples using a cheap colorimetric paper, including milk. We leverage the urease catalysis reaction to amplify the presence of heavy metal ions, Hg and Pb, by exploiting their strong inhibitory effect on urease.
View Article and Find Full Text PDFMechanoreceptor Piezo1 channel-Mediated Interleukin Expression in Conjunctival Epithelial Cells: Linking Mechanical Stress to Ocular Inflammation.
Ocul Surf
January 2025
Department of Physiology, Showa University Graduate School of Medicine, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-8555, Japan.
Purpose: Mechanical stress on the ocular surface, such as from eye-rubbing, has been reported to lead to inflammation and various ocular conditions. We hypothesized that the mechanosensitive Piezo1 channel in the conjunctival epithelium contributes to the inflammatory response at the ocular surface after receiving mechanical stimuli.
Methods: Human conjunctival epithelial cells (HConjECs) were treated with Yoda1, a Piezo1-specific agonist, and various allergens to measure cytokine expression levels using qRT-PCR.
Exploring Occupational Health Challenges in Pathology: A Cross-Sectional Survey of Indian Pathologists.
Cureus
December 2024
Pathology, BLDE (Deemed to be University) Shri B.M. Patil Medical College, Hospital, and Research Centre, Vijayapura, IND.
Introduction Occupational health hazards are a significant concern for pathologists due to their unique work environment. These professionals face risks from prolonged microscope use, exposure to chemicals such as formalin, and handling sharp instruments, leading to issues such as musculoskeletal disorders and needlestick injuries. Addressing these hazards is crucial for their well-being and the overall efficiency of medical diagnostics.
View Article and Find Full Text PDFAIE-active Circularly Polarized Thermally Activated Delayed Fluorescence Emitters for Stable Solution-Processed Circularly Polarized Electroluminescence.
Chemistry
January 2025
Nanjing University of Posts and Telecommunications, Institute of Advanced Materials (IAM), 9 Wenyuan Road, Nanjing 210023, China., Nanjing, CHINA.
Circularly polarized organic light-emitting diodes (CP-OLEDs) have significant promise for naked-eye 3D displays. However, most devices are fabricated using vacuum deposition technology, and development of efficient solution-processed CP-OLEDs, particularly those exhibiting low efficiency roll-off, remains a formidable challenge. This research successfully designed and synthesized two pairs of thermally activated delayed fluorescence (TADF) enantiomers through isomer engineering, namely (R/S)-N-5-TPA and (R/S)-N-4-TPA, which features fifth and fourth substitution sites of phthalimide (acceptor) by tri-phenylamine (donor), respectively.
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