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The Impact of Embryo Quality on Pregnancy Outcomes in Single Day 5 versus Day 6 Euploid Blastocyst Transfer: A Retrospective Cohort Study. | LitMetric

AI Article Synopsis

  • The study aimed to compare clinical outcomes of embryo transfers using euploid blastocysts based on their timing (D5 vs. D6) and quality.
  • Results showed that D5 embryos had a significantly higher live birth rate (55.04%) compared to D6 embryos (38.71%), with embryo quality being a key factor in these outcomes.
  • The findings suggest that selecting excellent quality D5 embryos leads to better IVF success rates, impacting decisions made by IVF teams and patients.

Article Abstract

Background: Selecting embryos with the highest implantation potential is crucial for fertilization (IVF) success. Both the timing of blastulation, day 5 (D5) or D6, and the embryo quality have been suggested as influential factors in determining the clinical outcome of single euploid blastocyst transfers. However, evidence supporting the superiority of D5 over D6 blastocysts remains inconclusive. The aim of this study was to compare clinical outcomes following the transfer of euploid blastocysts with different quality and timing of blastulation.

Materials And Methods: A retrospective cohort study was conducted at our Assisted Reproductive Center, analyzing the outcome of 774 transfers with D5 euploids and 155 transfers with D6 euploids performed between January 2019 and February 2022.

Results: The live birth rate was significantly lower in the euploid D6 group compared to the euploid D5 group (38.71vs. 55.04%, P=0.001). The outcome was significantly influenced by the quality of the embryos. Live birth rates were 62.14 and 53.61% following transfers of D5 and D6 excellent embryos respectively, 45.18 and 32.21% following transfer of D5 and D6 good embryos but only 28.64 and 19.32% following transfer of D5 and D6 fair embryos. The outcome difference was statistically significant across embryo quality categories (P=0.001). The adjusted risk ratios (RR) of clinical outcomes indicated that excellent euploid D5 embryos consistently outperformed other types of embryo quality.

Conclusion: The timing of blastulation and embryo quality are crucial factors in determining the success of single euploid blastocyst transfers. Excellent euploid D5 transfers yielded superior clinical outcomes, providing valuable insights for IVF teams and patients when selecting embryos to be transferred.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11245590PMC
http://dx.doi.org/10.22074/ijfs.2023.2006100.1488DOI Listing

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