Objectives: This retrospective study aimed to evaluate the risk factors (age and breed group) associated with Angiostrongylus vasorum and Crenosoma vulpis infection in dogs.
Materials And Methods: Faecal examinations obtained in dogs from January 2016 to December 2021 as part of routine clinical practice at two veterinary clinics in the Odsherred region of Zealand, Denmark, were included in this study. Faecal samples were analysed using the Baermann technique for nematode detection. Samples were collected from two clinics located in Northwestern Zealand, Denmark. Multinomial regression analysis, quasi-Poisson models and a generalised additive model for linearity were used to analyse the data.
Results: A total of 2,013 faecal samples were included in the study. Age was a significant risk factor for a positive Baermann, with a negative linear relationship observed (A. vasorum odds ratio: 0.80, 95% confidence interval: 0.70 to 0.91, C. vulpis odds ratio: 0.95, 95% confidence interval: 0.91 to 0.99, both nematodes: odds ratio: 0.87, 95% confidence interval: 0.77 to 0.99). Breed group analysis considering retrievers and flushing and water dog as reference group, demonstrated that sheep- and cattle dogs had a reduced risk of C. vulpis infection (odds ratio: 0.49, 95% confidence interval: 0.24 to 0.97), whereas dachshunds had an increased risk of A. vasorum infection (odds ratio: 3.28, 95% confidence interval: 1.14 to 9.47). Variations in the number of nematodes was found, with companion and toy dogs exhibiting higher numbers of C. vulpis (incidence rate ratio: 21.40, 95% confidence interval: 2.88 to 159) and sheep- and cattle dogs displaying higher numbers of A. vasorum (incidence rate ratio: 30.20, 95% confidence interval: 7.33 to 125). The prevalence rates of C. vulpis and A. vasorum were estimated at 14.50% (95% confidence interval: 13 to 16.10) and 3.40% (95% confidence interval: 2.70 to 4.30), respectively.
Clinical Significance: There are significant risk factors for nematode infection in dogs that can be considered for proper preventive care of this condition.
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http://dx.doi.org/10.1111/jsap.13762 | DOI Listing |
Vaccines (Basel)
December 2024
Division of Pediatric Infectious Diseases, UCLA David Geffen School of Medicine, Los Angeles, CA 90095, USA.
Objectives: SARS-CoV-2 infection is a known risk factor for adverse health outcomes in pregnancy, affecting both maternal and neonatal health. Mounting evidence suggests that even a single dose of an approved COVID-19 vaccine protects against severe SARS-CoV-2 infection and is safe for both pregnant persons and neonates. Southern Brazil was heavily affected by the COVID-19 pandemic, and the protective effects of the vaccine on maternal and neonatal health are not well described.
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November 2024
Bill & Melinda Gates Foundation, Seattle, WA 98109, USA.
Although wild poliovirus type 2 has been eradicated, the prolonged transmission of the live- attenuated virus contained in the type-2 oral polio vaccine (OPV2) in under-immunized populations has led to the emergence of circulating vaccine-derived poliovirus type 2 (cVDPV2). The novel OPV2 (nOPV2) was designed to be more genetically stable and reduce the chance of cVDPV2 emergence while retaining comparable immunogenicity to the Sabin monovalent OPV2 (mOPV2). This study aimed to estimate the relative reduction in the emergence risk due to the use of nOPV2 instead of mOPV2.
View Article and Find Full Text PDFPharmaceutics
December 2024
Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China.
Background: Achieving a balance between stable drug loading/delivery and on-demand drug activation/release at the target sites remains a significant challenge for nanomedicines. Carrier-free prodrug nanoassemblies, which rely on the design of prodrug molecules, offer a promising strategy to optimize both drug delivery efficiency and controlled drug release profiles.
Methods: A library of doxorubicin (DOX) prodrugs was created by linking DOX to fatty alcohols of varying chain lengths via a tumor-responsive disulfide bond.
Pharmaceutics
November 2024
Laboratory of Regulatory Science, Faculty of Pharmacy, Musashino University, Nishi-tokyo, Tokyo 202-8585, Japan.
Anticoagulant therapy, particularly the use of direct oral anticoagulant agents (DOACs), is recommended for patients with nonvalvular atrial fibrillation (NVAF). This multicenter observational retrospective cohort study aimed to assess the efficacy and safety of DOACs compared to warfarin in Japanese patients aged 75 years and older with NVAF. Data from the Mie-Life Innovation Promotion Center Database were used to collect medical information on the patients.
View Article and Find Full Text PDFToxics
December 2024
Medical Center for Neck and Low Back Pain, Xijing Hospital, Fourth Military Medical University, Xi'an 710000, China.
This study investigates the correlation between short-term exposure to nitrogen dioxide (NO) and hospitalization for chronic kidney disease (CKD) in Lanzhou, China. A distributed lag nonlinear model (DLNM) was employed to examine the relationship between changes in NO concentration and CKD hospitalizations. Subgroup analyses were conducted to assess the sensitivity of different populations to NO exposure.
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