Peripheral nerve injuries are prevalent and their treatments present significant challenges. Among the various reconstructive options, nerve conduits and wraps are popular choices. Advances in bioengineering and regenerative medicine have led to the development of new biocompatible materials and implant designs that offer the potential for enhanced neural recovery. Cost, nerve injury type, and implant size must be considered when deciding on the ideal reconstructive option.
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| http://dx.doi.org/10.1016/j.hcl.2024.03.003 | DOI Listing |
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Beyond One-Size-Fits-All: Pioneering a Zone-Based Strategy in Digital Nerve Autografting.
Ann Plast Surg
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Background: Digital nerve injuries significantly affect hand function and quality of life, necessitating effective reconstruction strategies. Autologous nerve grafting remains the gold standard due to its superior biocompatibility, despite recent advancements in nerve conduits and allogenic grafts. This study aims to propose a novel zone-based strategy for donor nerve selection to improve outcomes in digital nerve reconstruction.
View Article and Find Full Text PDFCost-Effective Production of Bacterial Cellulose and Tubular Materials by Cultivating B-11267 on a Molasses Medium.
Polymers (Basel)
January 2025
Department of Biotechnology, Biochemistry and Bioengineering, National Research Ogarev Mordovia State University, 430005 Saransk, Russia.
An original design of a simple bioreactor was used to fabricate two tubular, 200 cm long BC structures by culturing B-11267 on a molasses medium. In addition, a tubular BC-based biocomposite with improved mechanical properties was obtained by combining cultivation on the molasses medium with in situ chemical modification by polyvinyl alcohol (PVA). Moreover, the present study investigated the BC production by the B-11267 strain on the media with different molasses concentrations under agitated culture conditions.
View Article and Find Full Text PDFAdhesive and Conductive Fibrous Hydrogel Bandages for Effective Peripheral Nerve Regeneration.
Adv Healthc Mater
January 2025
Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.
Peripheral nerve injury is a common disease resulting in reversible and irreversible impairments of motor and sensory functions. In addition to conventional surgical interventions such as nerve grafting and neurorrhaphy, nerve guidance conduits are used to effectively support axonal growth without unexpected neuroma formation. However, there are still challenges to secure tissue-mimetic mechanical and electrophysiological properties of the conduit materials.
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Front Cell Neurosci
January 2025
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Background: Following transection, nerve repair using the polylactic acid (PLA) conduit is an effective option. In addition, inosine treatment has shown potential to promote nerve regeneration. Therefore, this study aimed to investigate the regenerative potential of inosine after nerve transection and polylactic acid conduit repair.
View Article and Find Full Text PDFConductive hydrogel luminal filler for peripheral nerve regeneration.
Biomaterials
January 2025
School of Materials Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, 61005, Republic of Korea. Electronic address:
Peripheral nerve injuries impair quality of life due to pain and loss of sensory and motor functions. Current treatments like autografts and nerve guidance conduits (NGCs) have limitations in functional restoration. Luminal fillers can enhance the effectiveness of NGCs by providing beneficial intraneural environments.
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