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| http://dx.doi.org/10.1016/j.chest.2024.05.041 | DOI Listing |
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Introduction Chronic obstructive pulmonary disease (COPD) is a significant contributor to global morbidity and mortality. Despite well-established management protocols, treatment remains suboptimal due to high costs and mortality rates. This study aims to compare the impact of initial oxygenation status, Dyspnea, Eosinopenia, Consolidation, Acidemia, and Atrial Fibrillation (DECAF), and National Early Warning Score 2 (NEWS2) scores on management outcomes in COPD patients.
View Article and Find Full Text PDFPrognostic clinical characteristics and systemic immune inflammatory biomarkers in 520 inpatients with herpes zoster: a retrospective analysis based on tertiary care hospitals.
Eur J Dermatol
October 2024
Department of Dermatology, Ruhr-University Bochum, Bochum, Germany, Department of Dermatology, Christian Hospital Unna, Unna, Germany.
Article Synopsis
- Herpes zoster (HZ) significantly impacts individual and public health, and a study analyzed clinical and laboratory data from 520 hospitalized HZ patients to identify key prognostic indicators.* ! -
- Results showed that systemic immune inflammatory biomarkers (like NLR and PIV) were much higher in HZ patients than healthy individuals, with absolute eosinopenia being a strong predictor for herpes zoster ophthalmicus (HZO).* ! -
- Key findings linked immunosuppression to a higher risk of herpes encephalitis and longer hospital stays, while not receiving intravenous antiviral therapy increased the likelihood of postherpetic neuralgia.* !
Background Frailty is a clinical syndrome characterized by diminished strength, endurance, and physiological function that significantly increases vulnerability to adverse health outcomes, including infections. In the context of COVID-19, frailty has emerged as a critical risk factor for severe disease, complications, and mortality, particularly in older adults. The severity and fatality rates among the geriatric group were notably high, as the virus's pathogenesis, marked by prolonged inflammation, contributed to increased morbidity and mortality in this age group.
View Article and Find Full Text PDFPrognostic significance of eosinophil-to-platelet ratio and C-reactive protein in predicting adverse events during acute exacerbations of chronic obstructive pulmonary disease: A comprehensive observational study.
Lung India
November 2024
Department of Pulmonary Medicine, Shri M. P. Shah Government Medical College, Jamnagar, Gujarat, India.
Background: Biomarkers like sarcopenia, eosinopenia and C-reactive protein (CRP) may predict major adverse events including intubation, ICU admission, mortality and readmission in chronic obstructive pulmonary disease (COPD) exacerbations. We aimed to determine their prognostic utility and accuracy.
Methods: This was a prospective analysis of COPD patients hospitalised for acute exacerbation over one year.
Complete Blood Count in Children With COVID-19: A Predictor of Disease Severity.
Clin Pediatr (Phila)
October 2024
Division of Pediatric Hematology, Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.
Article Synopsis
- Blood count abnormalities are common in young COVID-19 patients, with atypical lymphocytes and eosinopenia being the main changes observed in those evaluated in emergency rooms.
- In a study of 93 children aged 0 to 10, the presence of underlying health issues significantly increased the likelihood of hospitalization, and higher neutrophil to lymphocyte ratios (NLR) were associated with severity.
- Eosinopenia emerged as a notable predictor of disease severity in hospitalized children, suggesting that specific CBC changes can provide insights into clinical outcomes for pediatric COVID-19 cases.
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