AI Article Synopsis
- HHV-8 (Kaposi sarcoma herpesvirus) is linked to serious illnesses including Kaposi sarcoma and lymphoproliferative disorders, particularly affecting transplant recipients.
- A case study highlighted a fatal outcome linked to HHV-8, prompting a review of its impact on immunocompromised patients and exploring disease transmission and the importance of screening donors and recipients.
- The study concludes that while HHV-8 diseases can be severe and multifaceted in transplant patients, the actual risk of donor-derived infections is not well understood and needs more research.
Article Abstract
Background: Human herpes virus 8 (HHV-8) or Kaposi sarcoma herpesvirus (KSHV) is an opportunistic oncovirus that causes multiple pathologic entities.
Methods: We present a case of fatal HHV-8-associated multisystem illness with disseminated Kaposi sarcoma and HHV8-associated lymphoproliferative disorder with systemic inflammation. We conducted a narrative review of the literature on HHV-8 in transplantation with a goal of illuminating the spectrum of HHV-8-associated diseases in this vulnerable population, modes of disease transmission, and the potential role for donor and recipient screening.
Results: HHV-8-associated KS, primary effusion lymphoma (PEL), multicentric Castleman disease (MCD), and KSHV inflammatory cytokine disorder (KICS) may affect transplant recipients; with the exception of KS, these conditions are rare but carry high morbidity and mortality.
Conclusion: HHV-8-associated diseases have diverse and protean manifestations in transplant recipients, with potentially fatal outcomes. HHV-8 seroprevalence among organ donors and the magnitude of risk for donor-derived HHV-8 infection or clinically significant disease remain unknown and require further study.
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| http://dx.doi.org/10.1111/tid.14334 | DOI Listing |
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