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Validity and reliability of local endemic language version of the SARI Sigma Scale questionnaire for assessing stigma in leprosy patients.
Front Public Health
January 2025
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Introduction: The Stigma Assessment and Reduction of Impact (SARI) Stigma Scale is an instrument developed to evaluate stigma in Leprosy patients. Despite existing versions in Indonesian, the absence of an endemic area language version of a reliable assessment tool presents a barrier to effective interventions in regions like Ambon. This study aims to evaluate the validity and reliability of the Ambonese-Malay Language of SARI Stigma Scale questionnaire.
View Article and Find Full Text PDFRelationship between Internet use and offline leisure activities among Chinese older adult people: a moderated mediation model.
Front Public Health
January 2025
School of Law, Chongqing University, Chongqing, China.
Background: The process of aging in Chinese society is accompanied by the concurrent development of the Internet. In recent years, the influence of Internet use on the activities of older adults has attracted growing interest and is now a significant focus of both public health and gerontological research. Nevertheless, there is a need for further empirical research in this area.
View Article and Find Full Text PDFValidation of the Children's International Cognitive Ability Resource (Ch-ICAR).
Behav Res Methods
January 2025
Faculty of Psychology and Educational Sciences, Department of Experimental Psychology, Ghent University, Henri Dunantlaan 2, 9000, Ghent, Belgium.
The International Cognitive Ability Resource, abbreviated ICAR, counters some of the practical problems researchers face when using good, but proprietary, licensed intelligence tests like the Wechsler tests, which include unfeasible administration times and financial costs. So far, ICAR has been validated for adolescents and adults in many countries, offering a viable test alternative for these populations. For use among children, however, the appropriateness of this resource was yet unknown.
View Article and Find Full Text PDFEmerging roles of exosomes in diagnosis, prognosis, and therapeutic potential in ovarian cancer: a comprehensive review.
Cancer Gene Ther
January 2025
Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Ovarian cancer is a leading cause of cancer-related deaths in women, and the development of chemoresistance remains a major challenge during and after its treatment. Exosomes, small extracellular vesicles involved in intercellular communication, have emerged as potential biomarkers and therapeutic targets in ovarian cancer. This review summarizes the current literature on differences in exosomal protein/gene expression between chemosensitive and chemoresistant ovarian cancer, and the effects of exosomal modifications on chemotherapeutic response.
View Article and Find Full Text PDFNonapoptotic caspase-3 guides C1q-dependent synaptic phagocytosis by microglia.
Nat Commun
January 2025
Department of Translational Neurobiology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187-8502, Japan.
Caspases are known to mediate neuronal apoptosis during brain development. However, here we show that nonapoptotic activation of caspase-3 at presynapses drives microglial synaptic phagocytosis. Real-time observation and spatiotemporal manipulation of synaptic caspase-3 in the newly established, mouse-derived culture system demonstrate that increased neuronal activity triggers localized presynaptic caspase-3 activation, facilitating synaptic tagging by complements.
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