AI Article Synopsis
- * A case is presented involving a 51-year-old woman who experienced an acute ischemic stroke, where tenecteplase was given via intraosseous access after standard intravenous access failed.
- * The patient's stroke symptoms improved significantly within 48 hours post-administration, suggesting that intraosseous delivery of tenecteplase could be a viable alternative when intravenous access is not possible.
Article Abstract
Intro: Current guidelines for acute ischemic stroke recommend timely administration of intravascular thrombolytic therapy to promote functional and neurologic outcomes. Tenecteplase is an emerging off-label therapy for this indication and being utilized by various institutions due to its simpler administration strategy. In emergent situations in which intravenous access cannot be obtained, intraosseous access is a viable option for medication administration. However, there has been minimal published cases to support the efficacy and safety of intraosseous administration of tenecteplase for acute ischemic stroke.
Case: We describe the case of a 51-year-old woman who developed acute ischemic stroke within our institution. Due to difficulty achieving intravenous access and time-dependent efficacy of thrombolytic therapy, the decision was made to administer tenecteplase by the intraosseous route. Stroke symptoms improved within 48 hours following administration without complication.
Conclusion: Intraosseous administration of tenecteplase may be considered for treatment of acute ischemic stroke if intravenous access is unattainable.
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| http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2024.107850 | DOI Listing |
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