The development of new polymer nanocomposites or antibacterial coatings is crucial in combating drug-resistant infections, particularly bacterial infections. In this study, a new chitosan polymer based nanocomposite reinforced with magnesium oxide nanopowders and carbon quantum dots was fabricated by sol-gel technique and coated on 316 L stainless steel. In order to gaining the optimal amount of components to achieve the maximum antibacterial properties, the effect of concentration of nanocomposite components on its antibacterial properties was investigated. Crystal structure, microstructure, elemental dispersion, size distribution, chemical composition and morphology of nanocomposite and coating were characterized with various analyses. The obtained results exhibited that the carbon quantum dot and magnesium oxide nanopowders were distributed uniformly and without agglomeration in the chitosan matrix and created a uniform coating. The antibacterial properties of the synthesized samples against Staphylococcus aureus bacteria (gram positive) were evaluated using disk diffusion and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) antibacterial tests. The inhibition growth zone formed around the antibiotic and nanocomposite 25 mg/ml under dark and light was about 32 and 14, 11 mm, respectively. Also, MIC and MBC values for final nanocomposite were 62.5 and 125 μg/ml, respectively.
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| http://dx.doi.org/10.1016/j.ijbiomac.2024.133693 | DOI Listing |
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