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Ethical Challenges of Artificial Intelligence in Medicine.
Cureus
November 2024
Cardiology, University of Arizona College of Medicine, Phoenix, USA.
Artificial intelligence (AI) and machine learning (ML) have become critical components in the transformation of healthcare. They offer enhanced diagnostic accuracy, personalized treatment plans, and support for clinical decision-making. However, with these advancements come significant ethical challenges, including concerns around transparency, bias, data privacy, and the potential displacement of healthcare professionals.
View Article and Find Full Text PDFTrauma Causing Complications After Cleft Lip Repair.
Cleft Palate Craniofac J
December 2024
Department of Plastic Surgery, National Heart Institute, East of Kailash, New Delhi, India.
A case series of early postoperative complications due to trauma following primary cleft lip repair has been presented. Out of 193 primary cleft lip repair performed over the past 4 years, 5 patients had trauma related complications, 2 had complete wound dehiscence, 2 had partial dehiscence, and 1 presented with bleeding. This is the first report on complications following trauma after cleft lip repair.
View Article and Find Full Text PDFComprehensive benchmarking of computational tools for predicting toxicokinetic and physicochemical properties of chemicals.
J Cheminform
December 2024
Laboratory of Environmental Chemistry and Toxicology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Ensuring the safety of chemicals for environmental and human health involves assessing physicochemical (PC) and toxicokinetic (TK) properties, which are crucial for absorption, distribution, metabolism, excretion, and toxicity (ADMET). Computational methods play a vital role in predicting these properties, given the current trends in reducing experimental approaches, especially those that involve animal experimentation. In the present manuscript, twelve software tools implementing Quantitative Structure-Activity Relationship (QSAR) models were selected for the prediction of 17 relevant PC and TK properties.
View Article and Find Full Text PDFDistribution and gender-specific differences of coronal plane alignment of healthy knee.
J Orthop Surg Res
December 2024
Nopparat Rajathanee Hospital, Bangkok, Thailand.
Background: Understanding optimal prosthesis alignment in TKA remains crucial despite ongoing debate. While current research focuses on osteoarthritic knees, a gap exists in characterizing healthy young adult knees in Asians. This study aims to fill this gap by identifying the distribution of CPAK phenotypes in this population, including potential gender variations and individual differences.
View Article and Find Full Text PDFTwo cases of mixed large cell neuroendocrine carcinoma and adenocarcinoma of the cervix: case report and review of the literature.
Diagn Pathol
December 2024
Department of Pathology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang Province, 321000, China.
Background: Mixed adenoneuroendocrine carcinoma (MANEC) of the cervix is a rare malignant tumor with high malignancy and poor prognosis, of which large-cell neuroendocrine carcinoma and HPV-independent adenocarcinoma are particularly rare, which have been reported limitedly in the literature. Here, we present 2 cases of MANEC of the cervix and discuss important considerations for diagnosing cervical poorly differentiated carcinoma.
Case Presentation: we reported two cases of mixed large cell neuroendocrine carcinoma and adenocarcinoma of the cervix, one HPV-independent and one HPV-associated, both with vaginal bleeding.
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