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Generation of the human iPSC line ESi132-A from a patient with retinitis pigmentosa caused by a mutation in the PRPF31 gene.
Stem Cell Res
December 2024
Department of Integrative Pathophysiology and Therapies, Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Junta de Andalucía, CSIC, Universidad de Sevilla, Universidad Pablo de Olavide, Avda. Américo Vespucio 24, 41092 Seville, Spain.
Mutations in the PRPF31 gene are a well-known cause of autosomal dominant retinitis pigmentosa (RP), the most prevalent genetic form of blindness in adults, affecting 1 in 4,000 individuals globally. In this study, peripheral blood mononuclear cells from a patient carrying a heterozygous mutation in PRPF31 were reprogrammed to generate the human iPSC line ESi132-A. This cell line was thoroughly characterized for self-renewal and pluripotency.
View Article and Find Full Text PDFAn innovative ear transplantation for vascularized composite allotransplantation research in porcine model.
Sci Rep
December 2024
Pharmacology Research Group, Universidad del Valle, Colombia, Cali, 760043.
Vascularized composite allotransplantation (VCA) represents a clinical challenge for transplant therapy, as it involves different tissues with unique immunogenicity. Even when receiving immunosuppressive therapy, they are more vulnerable to severe hypoxia, microvascular damage, and ultimately the rejection or chronic graft dysfunction after transplantation. This study aimed to develop a surgical protocol for VCA of the ear in a porcine biomodel in the absence of immunosuppression, maintaining the in vitro co-culture of the allograft and assessing their relationship with allograft survival.
View Article and Find Full Text PDFNeurocircle microsurgery model: Description of simulation-based training and exoscope.
Surg Neurol Int
November 2024
Department of Neurosurgery, Neurozone 3D Research Center, Lima, Peru.
Background: Microsurgery is crucial in neurosurgery, requiring precise skills for interventions on delicate structures. Effective training is essential for developing these skills. In Peru and Latin America, however, there is a notable shortage of specialized training centers and high costs associated with foreign simulators, hindering the development of neurosurgical skills.
View Article and Find Full Text PDFThree-dimensional models demonstrate differences in correction depending on femoral derotational osteotomy site and may enhance the planning and precision in femoral derotational osteotomy - An observational study in eight femora and two surgeons.
Knee
January 2025
Department of Orthopedic Surgery and Traumatology, Clínica Universidad de Navarra, Pamplona, Spain.
Background: Increased femoral anteversion (FAV) is crucial in the genesis of anterior knee pain (AKP) and a femoral derotational osteotomy (FDO) has demonstrated good clinical results. It remains unclear at what level of the femur the osteotomy should be performed. Resulting degrees of FAV measured by Murphy's method do not always correspond to the degrees that had been planned after an FDO.
View Article and Find Full Text PDFOrbital Fractures Treated in Auckland From 2016 to 2020: Review of Patient Outcomes.
Craniomaxillofac Trauma Reconstr
February 2024
Department of Oral and Maxillofacial Surgery, Auckland & Counties Manukau District Health Board, Auckland, New Zealand.
Article Synopsis
- Orbital reconstruction surgery involves precise implant placement to restore the eye socket's shape, and new technologies like intra-operative CT and rapid-prototype biomodels are being tested to see if they can reduce post-operative complications.
- A retrospective study evaluated the effects of these technologies on issues like diplopia (double vision), altered sensation, cosmetic results, and the ability to return to work in patients with isolated orbital fractures.
- Results showed that using intra-operative CT and RP biomodels reduced the incidence of post-operative diplopia without significant differences in other complications, validating the use of these technologies in surgery.
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