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2024 White Paper on Recent Issues in Bioanalysis: Three Way-Cross Validation; Urine Clinical Analysis; Automated Methods; Regulatory Queries on Plasma Protein Binding; Automated Biospecimen Management; ELN Migration; Ultra-Sensitivity Mass Spectrometry ( - Recommendations on Advanced Strategies for Mass Spectrometry Assays, Chromatography, Sample Preparation and BMV/Regulated Bioanalysis - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV).
Bioanalysis
January 2025
US FDA, Silver Spring, MD, USA.
The 18 Workshop on Recent Issues in Bioanalysis (18 WRIB) took place in San Antonio, TX, USA on May 6-10, 2024. Over 1100 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest in bioanalysis. The 18 WRIB included 3 Main Workshops and 7 Specialized Workshops that together spanned 1 week to allow an exhaustive and thorough coverage of all major issues in bioanalysis of biomarkers, immunogenicity, gene therapy, cell therapy and vaccines.
View Article and Find Full Text PDF[Brain sagging dementia-A rare potentially reversible cause of dementia].
Nervenarzt
January 2025
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
African Swine Fever in Saxony-Disease Dynamics.
Viruses
December 2024
Friedrich-Loeffler-Institut Institute of Epidemiology, Südufer 10, 17493 Greifswald-Insel Riems, Germany.
African swine fever (ASF) emerged in Germany in 2020. A few weeks after the initial occurrence, infected wild boar were detected in Saxony. In this study, data from wild boar surveillance in Saxony were analyzed.
View Article and Find Full Text PDFValidation of the Black-&-White sign to predict intracerebral hematoma expansion in the multi-center PREDICT study cohort.
Int J Stroke
January 2025
Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada.
Article Synopsis
- Hematoma expansion (HE) occurs in a significant portion of patients with acute intracerebral hemorrhage (ICH), impacting their outcomes; the study focuses on the predictive accuracy of the Black-&-White (B&W) sign in identifying HE.
- In a multicenter cohort from the PREDICT study, the association between the B&W sign and HE was analyzed, revealing that patients with the B&W sign had a higher frequency of HE and more substantial growth of hematomas compared to those without it.
- The B&W sign strongly predicts HE, with an adjusted odds ratio of 7.83 for HE and 5.67 for severe HE, indicating that its presence significantly increases the risk of hematoma expansion.
The Life and Legacy of Samuel Hahnemann: Founder of Homoeopathy and His Medical Philosophy.
Cureus
September 2024
Central Research Facility, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Dr. Christian Friedrich Samuel Hahnemann (1755) was the visionary founder of homoeopathy, a system of medicine that emerged amidst the orthodox practices of his time. This biography traces Hahnemann's journey from a curious scholar in Meissen to a pivotal figure in global healthcare.
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