AI Article Synopsis
- Scientists have found a new way to see tiny changes in proteins very quickly, which is important for biology and medicine.
- They used special X-ray lasers that can take pictures millions of times a second without much background noise.
- This new method helps them study how proteins unfold and change shape, making it useful for understanding many different biological processes.
Article Abstract
Detecting microsecond structural perturbations in biomolecules has wide relevance in biology, chemistry and medicine. Here we show how MHz repetition rates at X-ray free-electron lasers can be used to produce microsecond time-series of protein scattering with exceptionally low noise levels of 0.001%. We demonstrate the approach by examining Jɑ helix unfolding of a light-oxygen-voltage photosensory domain. This time-resolved acquisition strategy is easy to implement and widely applicable for direct observation of structural dynamics of many biochemical processes.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11399097 | PMC |
| http://dx.doi.org/10.1038/s41592-024-02344-0 | DOI Listing |
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