AI Article Synopsis
- - This chapter discusses the rising importance of mesenchymal stromal/stem cells (MSCs) in regenerative medicine and highlights their applications in advanced therapy medicinal products (ATMPs).
- - It emphasizes advancements in cell culture technologies that enable large-scale MSC production while adhering to Good Manufacturing Practices (GMP) for safety and efficacy.
- - The text presents an optimized upstream protocol for laboratory-scale MSC production from various tissue sources, which is crucial for effective downstream processing and clinical applications.
Article Abstract
This chapter introduces the increasing significance of mesenchymal stromal/stem cell (MSC) production in regenerative medicine and cellular therapeutics, outlines the growing interest in MSCs for various medical applications, and highlights their potential in advanced therapy medicinal products (ATMPs) and the advancements in cell culture technologies that have facilitated large-scale MSC production under Good Manufacturing Practices (GMP), ensuring safety and efficacy. This chapter describes an optimized upstream protocol for laboratory-scale MSC production from different tissue sources. This protocol, conducted in flasks, controls critical parameters and lays the foundation for downstream processing to generate ATMPs. This comprehensive approach underscores the potential of MSCs in clinical applications and the importance of tailored production processes.
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| http://dx.doi.org/10.1007/7651_2024_553 | DOI Listing |
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