AI Article Synopsis

  • * A study at a Polish hospital found that while only 1 case of MC was recorded from 2015 to 2019, there were 10 cases reported during and after the pandemic, highlighting a concerning trend.
  • * Factors contributing to the increase included worsening hypothyroidism due to non-compliance with therapy, as well as difficulties in accessing required medication, emphasizing the need for better patient communication and ongoing primary care for those with thyroid issues.

Article Abstract

The COVID-19 pandemic was a major challenge for all health care employees, but it was also difficult for patients to gain access to health care services. Myxedema coma (MC) is an extremely rare but potentially fatal endocrine emergency. The aim of the study was to report an increased incidence of life-threatening myxedema coma that occurred in relation to the COVID-19 pandemic. In this paper, we report a cohort of 11 patients with MC who were treated at the University Hospital in Krakow, Poland, in the period from 2015 to 2023. Only 1 case of MC was recorded in the period from 2015 to 2019, and, in the same area, 10 cases of MC were recorded after the start of COVID-19 pandemic until present. Hypothyroidism was diagnosed de novo in 2 (18%) patients; the remaining patients were severely hypothyroid due to therapy non-compliance. Nine patients had primary hypothyroidism, and 2 had central hypothyroidism. Besides longstanding hypothyroidism, an additional precipitating factor for MC was identified in 4 (36%) of the patients. Due to the inaccessibility of parenteral levothyroxine, patients were treated with oral, mostly liquid, form of levothyroxine. The mortality rate in this cohort was 27.2%. In conclusion, the increase of the incidence of MC, which is a life-threatening complication of inadequately treated hypothyroidism, during the COVID-19 pandemic, when resources were limited, and in the post-pandemic era, underlines the importance of adequate communication with patients and of long-term availability of primary care for patients with thyroid disease.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467063PMC
http://dx.doi.org/10.1007/s11739-024-03690-9DOI Listing

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