AI Article Synopsis
- The study examines a 1:1 cocrystal of a specific aromatic compound and acetic acid to explore how fluorine (F) atoms enhance π-π interactions in the molecular structure.
- The cocrystal's structure is analyzed using crystallographic techniques, revealing hydrogen bonding and significant π-π interactions between the molecules.
- Results indicate that the presence of fluorine atoms plays a crucial role in facilitating these interactions without the need for complete halogenation of the aromatic ring.
Article Abstract
Using a 1:1 cocrystal of (E)-N-(3,4-difluorophenyl)-1-(pyridin-4-yl)methanimine with acetic acid, CHFN·CHO, we investigate the influence of F atoms introduced to the aromatic ring on promoting π-π interactions. The cocrystal crystallizes in the triclinic space group P1. Through crystallographic analysis and computational studies, we reveal the molecular arrangement within this cocrystal, demonstrating the presence of hydrogen bonding between the acetic acid molecule and the pyridyl group, along with π-π interactions between the aromatic rings. Our findings highlight the importance of F atoms in promoting π-π interactions without necessitating full halogenation of the aromatic ring.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299205 | PMC |
| http://dx.doi.org/10.1107/S2053229624005187 | DOI Listing |
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