A method for the synthesis of furans bearing indoline skeletons was developed an intramolecular palladium-catalyzed 5- cyclization/etherification cascade of -propargyl arylamines containing a 1,3-dicarbonyl side chain. This method realized the first capture of vinyl carbopalladiums by ketones as -nucleophiles and showed a wide range of substrate tolerability affording trisubstituted furans in various yields. The enantioselective version for this domino process and diverse derivatizations of the reaction products were also studied.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4cc02255f | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pd-catalyzed 5- cyclization/etherification cascade of -propargyl arylamines for the synthesis of polysubstituted furans.
Chem Commun (Camb)
July 2024
State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China.
A method for the synthesis of furans bearing indoline skeletons was developed an intramolecular palladium-catalyzed 5- cyclization/etherification cascade of -propargyl arylamines containing a 1,3-dicarbonyl side chain. This method realized the first capture of vinyl carbopalladiums by ketones as -nucleophiles and showed a wide range of substrate tolerability affording trisubstituted furans in various yields. The enantioselective version for this domino process and diverse derivatizations of the reaction products were also studied.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!