AI Article Synopsis
- Small cell carcinoma of the esophagus (SCCE) is a rare and aggressive cancer with no established treatment options, leading to difficulties in response to standard therapies.
- This study reports on the treatment of three SCCE patients (one with extensive-stage and two with limited-stage) using neoadjuvant chemoimmunotherapy, with limited-stage patients showing significant and lasting positive results post-surgery.
- Detailed analysis showed that the presence of CD8 T cells and PD-L1 expression in the tumors were crucial for the successful responses to the chemoimmunotherapy in these patients.
Article Abstract
Small cell carcinoma of the esophagus (SCCE) is a rare and highly malignant type of esophageal cancer with no standard treatment, facing challenges of resistance to conventional therapies. This study presents the cases of one extensive-stage and two limited-stage SCCE patients treated with chemoimmunotherapy. The two limited-stage patients underwent surgery post-treatment and experienced notable and enduring positive responses. This represents the first documented application of neoadjuvant chemoimmunotherapy in limited-stage SCCE patients. Additionally, comprehensive immunohistochemical analysis and whole exome sequencing were performed on the case patients. The findings revealed that infiltration of CD8 T cells and PD-L1 expression in the SCCE tumor were key factors for favorable responses in SCCE patients receiving chemoimmunotherapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11229733 | PMC |
| http://dx.doi.org/10.1080/21645515.2024.2370085 | DOI Listing |
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