AI Article Synopsis
- The study investigates the prevalence and significance of autoantibodies in children with metabolic dysfunction-associated steatotic liver disease (MASLD).
- Among 689 MASLD patients, 28% tested positive for antinuclear antibodies (ANA) and antismooth muscle antibodies (ASMA), while 15% had actin-positive antibodies and 17% showed elevated immunoglobulin G.
- ASMA positivity was linked to more severe liver fibrosis and higher disease activity scores, suggesting that certain autoantibodies may indicate increased severity in pediatric MASLD cases.
Article Abstract
Significance of autoantibodies in pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) is unknown. Our aim was to determine the prevalence and significance of autoantibodies in MASLD. PubMed and Scopus were searched and six articles (689 [487 males] MASLD patients) were identified. Antinuclear antibodies (ANA) was positive in 28% (95% confidence interval [CI]: 17%-39%, n = 6 studies), antismooth muscle antibodies (ASMA) in 28% (95% CI: 8%-50%, n = 5 studies), actin-positive in 15% (95% CI: 10%-20%, n = 2 studies) and elevated immunoglobulin G in 17% (95% CI: 1%-39%, n = 4 studies). Anti-liver-kidney-microsomal antibody was not present in any patient. There was no significant association of ANA positivity with degree of liver steatosis, liver fibrosis or nonalcoholic fatty liver disease activity score (NAS) but patients with ASMA positivity had advanced fibrosis (pooled risk ratio [RR] 1.77; 95% CI 1.16-2.71) and higher risk of NAS ≥5 (pooled RR 1.21; 95% CI: 1.01-1.44, n = 2 studies, 243 patients). To conclude, non-organ specific autoantibodies are present in over one-fourth of children with MASLD and the presence of ASMA maybe associated with increased disease severity.
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| http://dx.doi.org/10.1002/jpn3.12311 | DOI Listing |
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