AI Article Synopsis
- Molecular cages are 3D structures that encapsulate guest molecules; this study compares a metallo-organic cage and an organic cage for their ability to hold the anticancer drug doxorubicin.
- The organic cage successfully forms a stable 1:1 inclusion complex with doxorubicin, while the metallo-organic cage disassembles when interacting with the drug.
- The organic cage exhibits low toxicity and retains drug delivery capabilities, making it a promising candidate for future drug delivery systems.
Article Abstract
Molecular cages are three-dimensional supramolecular structures that completely wrap guest molecules by encapsulation. We describe a rare comparative study between a metallo-organic cage and a fully organic analogous system, obtained by hydrazone bond formation self-assembly. Both cages are able to encapsulate the anticancer drug doxorubicin, with the organic cage forming a 1 : 1 inclusion complex with μM affinity, whereas the metallo-organic host experiences disassembly by interaction with the drug. Stability experiments reveal that the ligands of the metallo-organic cage are displaced in buffer at neutral, acidic, and basic pH, while the organic cage only disassembles under acidic conditions. Notably, the organic cage also shows minimal cell toxicity, even at high doses, whilst the doxorubicin-cage complex shows anti-cancer activity. Collectively, these results show that the attributes of the pure organic molecular cage are suitable for the future challenges of drug delivery using molecular cages.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11220577 | PMC |
| http://dx.doi.org/10.1039/d4sc02294g | DOI Listing |
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