AI Article Synopsis
- Head-down bed rest (HDBR) simulates the effects of weightlessness on the human body, particularly focusing on how it impacts the cardiovascular system over a 21-day period.
- *The study found that HDBR increased levels of various proteins related to cardiovascular diseases and processes like blood clotting and inflammation, suggesting negative effects on heart health.
- *Conversely, some proteins involved in essential functions like oxygen transport and cell structure decreased during the HDBR, indicating overall physiological stress on the body.
Article Abstract
Head-down bed rest (HDBR) is one of the models of the physiological effects of weightlessness used, among other things, to assess the effect of hypokinesia on the physiological systems of the human body and, first of all, on the cardiovascular system. The aim of the work was to study the effect of 21 days of HDBR factors on the cardiovascular system based on blood proteomic profile data. It was revealed that HDBR conditions led to an increase in the levels of proteins of the complement and the coagulation cascade systems, platelet degranulation, fibrinolysis, acute phase proteins, post-translational modification of proteins, retinol-binding protein 4 (RBP4), apolipoprotein B, which are associated with cardiovascular diseases, and other proteins that affect the functions of endothelial cells. Blood levels of proteins involved in cytoskeletal remodelling, oxygen transport, heme catabolism, etc. have been shown to decrease during HDBR.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11222959 | PMC |
| http://dx.doi.org/10.3389/fphys.2024.1375929 | DOI Listing |
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