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| http://dx.doi.org/10.3389/fphys.2024.1440736 | DOI Listing |
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Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut.
Signal Transduct Target Ther
January 2025
National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Oxidative stress plays a crucial role in organ aging and related diseases, yet the endogenous regulators involved remain largely unknown. This work highlights the importance of metabolic homeostasis in protecting against oxidative stress in the large intestine. By developing a low-input and user-friendly pipeline for the simultaneous profiling of five distinct cysteine (Cys) states, including free SH, total Cys oxidation (Sto), sulfenic acid (SOH), S-nitrosylation (SNO), and S-glutathionylation (SSG), we shed light on Cys redox modification stoichiometries and signaling with regional resolution in the aging gut of monkeys.
View Article and Find Full Text PDFDecoding the Nexus: Cellular and Molecular Mechanisms Linking Stroke and Neurotoxic Microenvironments in Brain Cancer Patients.
Biomolecules
November 2024
Global Health Neurology Lab, Sydney, NSW 2150, Australia.
Stroke is an often underrecognized albeit significant complication in patients with brain cancer, arising from the intricate interplay between cancer biology and cerebrovascular health. This review delves into the multifactorial pathophysiological framework linking brain cancer to elevated stroke risk, with particular emphasis on the crucial role of the neurotoxic microenvironment (NTME). The NTME, characterized by oxidative stress, neuroinflammation, and blood-brain barrier (BBB) disruption, creates a milieu that promotes and sustains vascular and neuronal injury.
View Article and Find Full Text PDFDecoding Correlations in Predatory Business Practices and Physicians' Strategies Against Daily Predatory Emails.
Cureus
November 2024
Intensive Care Medicine, Elisabeth-Tweesteden Hospital, Tilburg, NLD.
Introduction Predatory journals are marked by inadequate editorial practices and peer review processes, diverging from established global standards in scientific publishing. This article, as a component of the ASGLOS Study, aims to explore the relationship between participant demographics and their experiences with targeted predatory business activities, including their approaches to managing daily predatory emails. Methods To collect the personal experiences of physicians' mailboxes on predatory publishing, a Google Form® survey was designed and disseminated from September 2021 to April 2022.
View Article and Find Full Text PDFChromTR: chromosome detection in raw metaphase cell images via deformable transformers.
Front Med
December 2024
Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Shanghai, 200240, China.
Chromosome karyotyping is a critical way to diagnose various hematological malignancies and genetic diseases, of which chromosome detection in raw metaphase cell images is the most critical and challenging step. In this work, focusing on the joint optimization of chromosome localization and classification, we propose ChromTR to accurately detect and classify 24 classes of chromosomes in raw metaphase cell images. ChromTR incorporates semantic feature learning and class distribution learning into a unified DETR-based detection framework.
View Article and Find Full Text PDFNeural speech tracking and auditory attention decoding in everyday life.
Front Hum Neurosci
November 2024
Department of Psychology, Neuropsychology Lab, University of Oldenburg, Oldenburg, Germany.
Introduction: In our complex world, the auditory system plays a crucial role in perceiving and processing our environment. Humans are able to segment and stream concurrent auditory objects, allowing them to focus on specific sounds, such as speech, and suppress irrelevant auditory objects. The attentional enhancement or suppression of sound processing is evident in neural data through a phenomenon called neural speech tracking.
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