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Assessment and ascertainment in psychiatric molecular genetics: challenges and opportunities for cross-disorder research.
Mol Psychiatry
December 2024
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Psychiatric disorders are highly comorbid, heritable, and genetically correlated [1-4]. The primary objective of cross-disorder psychiatric genetics research is to identify and characterize both the shared genetic factors that contribute to convergent disease etiologies and the unique genetic factors that distinguish between disorders [4, 5]. This information can illuminate the biological mechanisms underlying comorbid presentations of psychopathology, improve nosology and prediction of illness risk and trajectories, and aid the development of more effective and targeted interventions.
View Article and Find Full Text PDF[Impact of manual-physical correction method on aerobic metabolism processes in patients with essential arterial hypertension].
Vopr Kurortol Fizioter Lech Fiz Kult
December 2024
S.I. Spasokukotsky Moscow Centre for Research and Practice in Medical Rehabilitation, Restorative and Sports Medicine of the Moscow Healthcare Department, Moscow, Russia.
Unlabelled: Essential arterial hypertension (EAH) is a chronic non-communicable disease (CNCD), that develops in parallel with other pathologies of the CNCD group, the presence of which is promoted by hypodynamia with consequent disturbance of aerobic energy supply processes. These disorders include, in particular, degenerative-dystrophic processes of the locomotor system, comprising of the cervical spine. In turn, development of these processes can additionally worsen hemodynamics with disturbance of the oxygen transfer processes.
View Article and Find Full Text PDFThe challenge and promise of disentangling neurodevelopmental conditions a commentary on Davis et al. (2024).
J Child Psychol Psychiatry
December 2024
Department of Psychology, University of Amsterdam, Amsterdam, The Netherlands.
This commentary evaluates the study by Davis et al. on the early behavioural manifestations of autism spectrum condition (ASC) and attention deficit hyperactivity disorder (ADHD) in preschool children. Davis et al.
View Article and Find Full Text PDFTranscriptomic clustering of chronic lymphocytic leukemia: molecular subtypes based on Bruton's tyrosine kinase expression levels.
Blood Cancer J
December 2024
Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Historically, CLL prognostication relied on disease burden, reflected in clinical stage. Later, chromosome abnormalities and genomics suggested several CLL subtypes which were aligned with response to therapy. Gene expression profiling data identified pathways associated with CLL progression.
View Article and Find Full Text PDF[Nosological aspects of the petrification and ossification processes in the lungs].
Arkh Patol
December 2024
St. Petersburg Research Institute of Phthisiopulmonology, St. Petersburg, Russia.
Microscopic changes in the lung biopsies of 16 adult patients of both sexes without clear clinical symptoms are described. According to X-ray examination data, disseminated process in the lungs was diagnosed in 4 patients, interstitial pneumonia in 4, osteoplastic pneumopathy in 3, as well as tuberculosis, bronchiolitis and a number of others. Microscopic examination showed that the patients had various forms of petrification and ossification of the lungs, diagnosed clinically and radiologically in only 3 cases.
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