AI Article Synopsis
- The study investigates the imaging characteristics of supratentorial ependymomas (STE), rare tumors primarily found in children, using CT and MRI scans from 25 patients.
- Key findings suggest that STEs often occur near ventricles and are associated with cystic components and specific imaging signs like the periwinkle sign.
- The research also highlights significant links between these imaging features and the presence of a particular genetic alteration (ZFTA fusion), aiming to improve diagnosis and treatment outcomes.
Article Abstract
Aim: Supratentorial ependymoma (STE) is a rare tumor with distinct genetic alterations, whose imaging features have been scarcely studied. This study aims to review the computed tomography (CT) and magnetic resonance imaging (MRI) features of a cohort of histopathologically proven STE to identify the distinguishing features of STE, and look for specific signs of zinc finger translocation associated (ZFTA) fused STEs.
Methods: Ethical clearance was obtained from the institutional ethics committee. The magnetic resonance (MR) images, CT images when available, clinical details, and pathological reports of 25 patients from a single institute with histopathologically proven STE were retrospectively reviewed. Imaging features, demographic details, pathological and molecular features, and type of surgical resection were described and tabulated. Relevant associations with imaging features were computed and tabulated.
Results: The study showed that STEs are common in the pediatric population with no sex predilection. The periventricular location was the most common. A significant association between periventricular location and the presence of a cystic component ( value = 0.023) and the presence of the periwinkle sign/stellate sign ( value = 0.045) was found. Common features of ZFTA fused STEs included periventricular or intraventricular location, cystic component, necrosis, and the periwinkle sign. A significant association was found between ZFTA fusion and cystic component ( value = 0.048).
Conclusions: This study attempts to identify the imaging features of STEs and their associations with molecular pathology and surgical outcome, and the distinguishing features of ZFTA fused STEs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11220288 | PMC |
| http://dx.doi.org/10.37349/etat.2024.00245 | DOI Listing |
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