AI Article Synopsis
- The study aims to evaluate the safety and effectiveness of a targeted form of Transcranial Magnetic Stimulation (rTMS) in patients suffering from post-concussive syndrome (PCS) after traumatic brain injuries (TBI).
- Researchers reviewed the experiences of 19 patients who underwent personalized rTMS treatment, identifying targets using advanced machine learning techniques to improve their quality of life and reduce symptoms.
- Results indicated significant improvements in overall well-being and reductions in symptoms of depression and anxiety among the patients, suggesting that this method could be a promising treatment for PCS, warranting further research.
Article Abstract
Objective: To determine the safety and proof of concept of a parcel-guided, repetitive Transcranial Magnetic Stimulation (rTMS) in patients who develop a heterogeneous array of symptoms, known collectively as post-concussive syndrome (PCS), following traumatic brain injury (TBI).
Methods: We performed a retrospective review of off-label, individualized, parcel-guided rTMS in 19 patients from December 2020 to May 2023. Patients had at least one instance of mild, moderate, or severe TBI and developed symptoms not present prior to injury. rTMS targets were identified based on machine learning connectomic software using functional connectivity anomaly matrices compared to healthy controls. EuroQol (EQ-5D), as a measurement of quality of life, and additional questionnaires dependent on individual's symptoms were submitted prior to, after, and during follow-up from rTMS.
Results: Nineteen patients showed improvement in EQ-5D and Rivermead Post Concussion Symptoms Questionnaires - 3 after treatment and follow-up. For nine patients who developed depression, five (55%) attained response and remission based on the Beck Depression Inventory after treatment. Eight of ten patients with anxiety had a clinically significant reduction in Generalized Anxiety Disorder-7 scores during follow-up.
Conclusion: Parcel-guided rTMS is safe and may be effective in reducing PCS symptoms following TBI and should incite further controlled studies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/02699052.2024.2371975 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Corticospinal and Clinical Effects of Muscle Tendon Vibration in Neurologically Impaired Individuals. A Scoping Review.
J Mot Behav
December 2024
Laboratoire de recherche Biomécanique & Neurophysiologique en Réadaptation neuro-musculo-squelettique, Centre intersectoriel en santé durable, Université du Québec à Chicoutimi, Chicoutimi, Canada.
This review verified the extent, variety, quality and main findings of studies that have tested the neurophysiological and clinical effects of muscle tendon vibration (VIB) in individuals with sensorimotor impairments. The search was conducted on PubMed, CINAHL, and SportDiscuss up to April 2024. Studies were selected if they included humans with neurological impairments, applied VIB and used at least one measure of corticospinal excitability using transcranial magnetic stimulation (TMS).
View Article and Find Full Text PDFAccurate determination of motor evoked potential amplitude in TMS: The impact of personal and experimental factors.
Clin Neurophysiol
December 2024
REVAL - Rehabilitation Research Center, Faculty of Rehabilitation Sciences, University of Hasselt, Diepenbeek, Belgium.
Objective: Corticospinal excitability can be quantified using motor-evoked potentials (MEP) following transcranial magnetic stimulation (TMS). However, the inherent variability of MEPs poses significant challenges. We establish a framework using personal and experimental factors to select the optimal number of trials (n) required for reliable MEP estimates.
View Article and Find Full Text PDFCorticospinal excitability is not facilitated by observation of asymmetric walking on a split-belt treadmill in humans.
Neuroreport
December 2024
Faculty of Health and Sports Science, Doshisha University, Kyotanabe, Kyoto, Japan.
The present study aimed to investigate changes in corticospinal excitability (CSE) by observing unnatural walking patterns on a treadmill with different left and right belt speeds. Fifteen healthy adults watched video clips (10 s each) of walking under the tied condition (left and right treadmill belt speeds are the same), walking during the initial and late periods under the split-belt condition (left and right treadmill belt speeds are different), and the static fixation cross (control condition) in random order. The step lengths of the actor in the walking clips were almost symmetric under the tied condition and during the late period under the split-belt condition but largely asymmetric during the initial period under the split-belt condition.
View Article and Find Full Text PDFIntermittent theta burst stimulation vs. high-frequency repetitive transcranial magnetic stimulation for post-stroke dysfunction: a Bayesian model-based network meta-analysis of RCTs.
Neurol Sci
December 2024
Department of Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian Province, 362000, China.
Objective: This research aims to comprehensively assess the efficacy of intermittent theta-burst stimulation (iTBS) vs. high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) in post-stroke dysfunction.
Materials And Methods: Until January 2024, extensive electronic database searches were conducted (PubMed, Embase, Cochrane Library, Web of Science, etc.
Transcranial Cortex-Wide Imaging of Murine Ischemic Perfusion With Large-Field Multifocal Illumination Microscopy.
Stroke
January 2025
Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zurich, Switzerland (Z.C., Q.Z., Y.-H.L., C.G., I.G., M.W., H.A.I.Y., D.R.K., B.W., D.R.).
Background: Ischemic stroke is a common cause of death worldwide and a main cause of morbidity. Presently, laser speckle contrast imaging, x-ray computed tomography, and magnetic resonance imaging are the mainstay for stroke diagnosis and therapeutic monitoring in preclinical studies. These modalities are often limited in terms of their ability to map brain perfusion with sufficient spatial and temporal resolution, thus calling for development of new brain perfusion techniques featuring rapid imaging speed, cost-effectiveness, and ease of use.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!