AI Article Synopsis
- - This study investigates whether cocoa and its polyphenol-rich fractions have anti-inflammatory effects in a mouse model of acute colonic inflammation induced by dextran sulfate sodium (DSS).
- - Male mice received dietary cocoa treatments for two weeks before and during DSS-induced inflammation, but cocoa did not prevent weight loss or reduced colon size, although it improved spleen enlargement.
- - Overall, the findings indicate that cocoa and cocoa polyphenols are not effective in reducing acute colonic inflammation, as evidenced by inflammatory markers and the similarity of treated mice to the control group subjected to DSS.
Article Abstract
Scope: A study is conducted to determine the anti-inflammatory effects of cocoa and polyphenol-rich cocoa fractions in the dextran sulfate sodium (DSS)-induced mouse model of acute colonic inflammation.
Methods And Results: Male C57BL/6J mice are treated with dietary cocoa powder, an extractable cocoa polyphenol fraction, or a non-extractable cocoa polyphenol fraction for 2 weeks prior to treatment with 2.5% DSS in the drinking water for 7 days to induce colonic inflammation. Cocoa treatment continues during the DSS period. Cocoa and/or cocoa fractions exacerbate DSS-induced weight loss and fail to mitigate DSS-induced colon shortening but do improve splenomegaly. Cocoa/cocoa fraction treatment fails to mitigate DSS-induced mRNA and protein markers of inflammation. Principal component analysis shows overlap between cocoa or cocoa fraction-treated mice and DSS-induced controls, but separation from mice not treated with DSS.
Conclusion: The results suggest cocoa and cocoa polyphenols may not be useful in mitigating acute colonic inflammation.
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| http://dx.doi.org/10.1002/mnfr.202400431 | DOI Listing |
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