AI Article Synopsis
- This review evaluates how hypercholesterolemia is factored into cardiovascular risk assessments in the general population and examines its integration into clinical risk scores.
- Recent findings indicate that the influence of hypercholesterolemia on risk varies by calculator, with early lipid levels significantly impacting atherosclerosis, regardless of later treatments.
- The study highlights the importance of understanding the interactions between LDL cholesterol, inflammation, and emerging diagnostic tools like polygenic risk scores and coronary artery calcium scores for better predicting and managing cardiovascular risk.
Article Abstract
Purpose Of The Review: This review aims to assess the variability in considering hypercholesterolemia for cardiovascular risk stratification in the general population. Recent literature on the integration of hypercholesterolemia into clinical risk scores and its interaction with other risk factors will be explored.
Recent Findings: The impact of hypercholesterolemia on risk estimation varies among different cardiovascular risk calculators. Elevated lipid levels during early life stages contribute to atherosclerotic plaque development, influencing disease severity despite later treatment initiation. The interplay between low-density lipoprotein cholesterol (LDLc), inflammatory markers and non-LDL lipid parameters enhances cardiovascular risk stratification. Studies have also examined the role of coronary artery calcium (CAC) score as a negative risk marker in populations with severe hypercholesterolemia. Furthermore, polygenic risk scores (PRS) may aid in diagnosing non-monogenic hypercholesterolemia, refining cardiovascular risk stratification and guiding lipid-lowering therapy strategies. Understanding the heterogeneity in risk estimation and the role of emerging biomarkers and imaging techniques is crucial for optimizing cardiovascular risk prediction and guiding personalized treatment strategies in individuals with hypercholesterolemia.
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| http://dx.doi.org/10.1007/s11883-024-01225-3 | DOI Listing |
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