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Cutaneous leishmaniasis and iron metabolism: current insights and challenges.
Front Immunol
December 2024
Health and Environment Laboratory, Hassan II University of Casablanca, Biochemistry, Biotechnology and Immunophysiopathology Research Team, Ain Chock Faculty of Sciences, Casablanca, Morocco.
Leishmaniasis is a vector-borne parasitic infection induced by protozoa of the genus The disease spectrum ranges from skin lesions to visceral leishmaniasis, which is fatal if untreated. The cutaneous leishmaniasis is characterized by a clinical polymorphism of lesions with a broad range of severity ranging from a self-limited lesion to multiple disfiguring lesions stigmatizing the patient for life. Although iron is required for several process of infection including survival, growth and virulence, the number of studies on host iron metabolism during this infection remains limited.
View Article and Find Full Text PDFMolecular characterization of the E2 conjugating enzyme LinfUbc13 in Leishmania infantum.
Arch Biochem Biophys
December 2024
Department of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. Electronic address:
UBC13 is an orthologue of Homo sapiens ubiquitin-conjugation E2 enzymes described in Leishmania mexicana, a null mutant lacking this gene cannot be produced, suggesting essential functions in this parasite. Leishmania infantum is an etiological agent of visceral leishmaniasis, the most severe type of disease that is potentially fatal if untreated. The ubiquitination process has been targeted for leishmanicidal compounds, indicating its essential function in parasite homeostasis.
View Article and Find Full Text PDFFatal visceral disseminated varicella zoster virus infection during initial remission induction therapy in a patient with lupus nephritis: a case report and review of the literature.
CEN Case Rep
December 2024
Department of Nephrology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Visceral disseminated varicella zoster virus (VZV) infection is a severe complication, characterized by a notably high mortality rate. Herein, we present a case of a 36-year-old-man involving visceral disseminated VZV infection that emerged during remission induction therapy involving high-dose prednisolone (PSL), mycophenolate mofetil (MMF), and hydroxychloroquine for lupus nephritis. Two months after starting the immunosuppressive therapy, he experienced a rapid onset of severe upper abdominal pain.
View Article and Find Full Text PDFFirst report of acute, visceral, fatal toxoplasmosis in a naturally infected calf (Bos taurus).
Vet Parasitol
December 2024
Idexx Laboratories Hamilton, 20A Maui Street, Pukete, Hamilton 3200, New Zealand.
Cattle are considered resistant to clinical toxoplasmosis and viable Toxoplasma gondii is rarely isolated from bovine tissues. Currently, there is no histologically confirmed case of clinical toxoplasmosis in cattle. Here, the first confirmed case of acute toxoplasmosis in cattle is reported.
View Article and Find Full Text PDFPrevalence of human visceral leishmaniasis and its risk factors in Eastern Africa: a systematic review and meta-analysis.
Front Public Health
December 2024
Department of Environmental Health, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Introduction: Visceral Leishmaniasis, also known as kala-azar, is a potentially fatal, neglected tropical disease caused by the protozoan parasite and transmitted through infected sandflies. It is one of the major global public health problems and contributors to economic crisis among people. Though different studies investigated human visceral leishmaniasis in Eastern Africa, the findings were inconsistent and inconclusive enough, and there is no representative data on this devastating public health concern.
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