AI Article Synopsis
- The text introduces the concept that viral cytopathic changes in sputum cytology have been noted for several viruses, but human metapneumovirus (hMPV) is not well-documented in this context.
- It presents a case study of a 63-year-old male patient with hMPV, detailing specific cytopathic changes observed in his sputum, like multinucleation and nuclear inclusions.
- The conclusion highlights the need to recognize hMPV's role in causing these changes and stresses the importance of distinguishing them from similar features caused by other viruses, as this can affect clinical management.
Article Abstract
Introduction: Viral cytopathic changes seen in sputum cytology have been described in association with infection by viruses such as cytomegalovirus (CMV), herpes simplex virus (HSV), adenovirus, and even measles. However, viral cytopathic changes due to human metapneumovirus (hMPV) have not yet been well described in cytology. hMPV is a relatively new entity, discovered in 2001. It is known to cause upper and lower respiratory tract infections in children, the elderly, and immunocompromised patients.
Case Presentation: We describe the viral cytopathic changes seen in sputum in a 63-year-old male patient with known hMPV. These changes include multinucleation, nuclear enlargement, homogenised nuclei, basophilic nuclear inclusions with perinuclear halos, and small eosinophilic cytoplasmic inclusions.
Conclusion: We aim to raise awareness that hMPV can cause viral cytopathic changes and to describe these cytological features, which have been elucidated in only 1 case report thus far. Distinction from other viruses with similar changes, such as HSV and CMV, is important due to their differing clinical implications.
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| http://dx.doi.org/10.1159/000540184 | DOI Listing |
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