Developing a pill to treat sickle cell disease.

Science

Laboratory of Gene Regulation, MRC Weatherall Institute of Molecular Medicine, and Chinese Academy of Medical Sciences Oxford Institute, University of Oxford, Oxford, UK.

Published: July 2024

A newly identified epigenetic modifier increases fetal hemoglobin in preclinical studies.

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.adq3757DOI Listing

Publication Analysis

Top Keywords

developing pill
4
pill treat
4
treat sickle
4
sickle cell
4
cell disease
4
disease newly
4
newly identified
4
identified epigenetic
4
epigenetic modifier
4
modifier increases
4

Similar Publications

Background: The incidence and mortality of lung cancer are high, and treatment with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is the preferred first-line treatment for patients suffering from non-small cell lung cancer (NSCLC) with EGFR mutations. However, EGFR-TKI resistance leads to treatment failure. Yifei-Sanjie pill (YFSJ) is a novel type of Chinese patent medicine for lung cancer.

View Article and Find Full Text PDF

Navigating DR-TB Treatment care: a qualitative exploration of barriers and facilitators to retention in care among people with history of early disengagement from drug-resistant tuberculosis treatment in Johannesburg, South Africa.

BMC Health Serv Res

January 2025

HIV and Other Infectious Diseases Research Unit (HIDRU), South African Medical Research Council: CAPRISA-MRC HIV-TB Pathogenesis and Treatment Research Unit, Free State, South Africa.

Background: Despite advances in drug-resistant tuberculosis (DR-TB) diagnosis, treatment, and service delivery, individuals with DR-TB often face significant socioeconomic and psychosocial challenges due to limited resources. These challenges can hinder retention in care, undermining the progress made in DR-TB management. As a consequence, advances in DR-TB diagnostics and treatment have not resulted in DR-TB programs meeting the 75% treatment success targets set by the World Health Organization (WHO).

View Article and Find Full Text PDF

Introduction: Acromioclavicular (AC) joint injuries pose significant challenges in clinical management, necessitating consensus guidelines for optimal treatment. There is a lack of consensus in several areas, including imaging protocols, surgical techniques, and rehabilitation timelines. This study aims to develop a consensus regarding the diagnosis, treatment, and rehabilitation of AC joint separations.

View Article and Find Full Text PDF

Significance: Women are at increased risk for mood disorders, which may be partly attributed to exposure to endocrine-disrupting chemicals (EDCs) during sensitive periods such as pregnancy. Exposure during these times can impact brain development in the offspring, potentially leading to mood disorders in later life. Additionally, fluctuating levels of endogenous estrogens, as seen during pregnancy, or the use of oral contraceptives, can further elevate this risk.

View Article and Find Full Text PDF

Study Design: A retrospective review of a prospective adult spinal deformity data.

Objective: To identify distinct patient clinical profiles and recovery trajectories in patients with adult spinal deformity (ASD).

Summary Of Background Data: Patients with ASD exhibit a diverse array of symptoms and significant heterogeneity in clinical presentations, posing challenges to precise clinical decision-making.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!